Influence of combinations of pro-inflammatory and anti-inflammatory cytokine gene polymorphisms on the course of chronic purulent otitis media
Author Affiliations1Chita State Medical Academy of Minzdrav of Russia, 672090, Chita, Gorky str., 39a
2Chita State Medical Academy of Minzdrav of Russia, 672090, Chita, Gorky str., 39a
Abstract
The results of occurrence of polymorphism of genotypes inflammatory and anti- inflammatory cytokines IL-1β (С3953Т, Т511С, Т31С), IL-6 (С174G), IL-10 (G1082A, C592A, C819T), and TNF-α (G308A) in 299 patients with chronic purulent otitis media and 183 healthy individuals of Transbaikal region are presented. The high values of IL-1β (19.4 ± 0.23 pg/ml) (p < 0.05) and low numbers of IL-10 (12.5 ± 0.12 pg/ml) (p < 0.05) in carriers of gene high-producing inflammatory cytokines and of allele slow-producing anti-inflammatory cytokines in individuals with caries-destructive course of chronic purulent otitis media have been revealed. The reliable confirmation of IL-6 and TNF-α gene polymorphism aggravating effect on the course of chronic otitis have been received in the study.
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References
- Bayke E.V., Lebedinskaya V.A. The impact socio-economic factors on the incidence chronic purulent otitis media and otogenic intracranial complications // Zabaykal'skiy meditsinskiy vestnik = The Transbaikalian medical bulletin. 2016. (1). 53-58. [In Rusian].
- Vare B. Analysis of genetic data: Discrete genetic traits. Moscow: Mir, 1995. [In Rusian].
- Gulomov Z.S., Simbirtsev A.S., Yanov Yu.K. et al. Role of cytokines in the treatment of acute and chronic diseases of the upper respiratory tract // Rossiyskaya otorinolaringologiya = Russian otorhinolaryngology. 2008. (6). 200-205. [In Rusian].
- DorzhievaN.E., VitkovskyYu.A., SudakovaL.R. IL-10 (C819T) gene polymorphism patients with inflammatory dental deaseases in Trans-Baikal region // Zabaykal'skiy meditsinskiy vestnik = The Transbaikalian medical bulletin. 2011. (1). 44-47. [In Rusian].
- KiselevaYe.A., ElbakidzeA.Z., NikolaevaO.Yu. Phenotypic role of cytokine gene polymorphisms in chronic inflammatory and neoplastic diseases of the dental // Tsitokiny i vospalenie = Cytokines and Inflammation. 2011. (4). 52-55. [In Rusian].
- Konenkov V.I., Prokofiev V.F., Shevchenko A.V. Prognostic signostic significance of lymphangiogenesis gene polymorphism in level of person health valuation // Byulleten' Sibirskogo otdeleniya Rossiyskoy akademii meditsinskikh nauk = Bulletin of Siberian Branch of Russian Academy of Medical Sciences. 2013. 33. (6). 51-59. [In Rusian].
- Mironov A.A.Chronic purulent otitis media // Vestnik otorinolaringologii = Bulletin of Otorhinolaryngology. 2011. (5). 72-76. [In Rusian].
- Rebrova O.Y. Statistical analysis of medical data. The application package Statistica applications. Moscow: MediaSfera, 2006. [In Rusian].
- Rydlovskaya A.V., Simbirtsev A.S. Functional gene polymorphisms TNF-α and pathology // Tsitokiny i vospalenie = Cytokines and Inflammation. 2005. (3). 4-10. [In Rusian].
- Simbirtsev A.S., Gromova A.Yu., Rydlovskaya A.V. The role of polymorphisms of genes of cytokines in the regulation of inflammation and immunity// Meditsinskiy akademicheskiy zhurnal = Medical academic journal. 2006. (1). 144-149. [In Rusian].
- Sovalkin V.I., Pomorgaylo Ye.G., Sabitova O.N.et al. The role of tumor necrosis factor-α G–308A, interleukin-1β C–511T and interleukin -10 G–1082A gene polymorphism in the development of slowly resolved course of community-acquired pneumonia // Byulleten' sibirskoy meditsiny = Bulletin of Siberian medicine. 2013. (6). 54–61. [In Rusian].
- Terskova N.V.,Vakhrushev S.G., Shnayder N.A. The additive contribution of single nucleotide replacements of a tumor necrosis factor α gene to chronic adenoiditis predisposition // Rossiyskaya otorinolaringologiya = Russian otorhinolaryngology. 2011. (6). 142-153. [In Rusian].
- Tikhomirova I.A. Chronic diseases of ENT organs in the formation of the profile: abstract of thesis …doctor of medical sciences. Saint-Petersburg, 2009. [In Rusian].
- Shevchenko A.V., Konenkov V.I., Golovanova O.V. Features of the IL-1, IL-4, IL-5, IL-6, IL-10 and TNF-α cytokine genes promoter polymorphism of Western Siberia Caucasoid population // Immunologiya = Immunology. 2010. (4). 176-181. [In Rusian].
- Patel J.A. Association of proinflammatory cytokine gene promoter polymorphisms with susceptibility to otitis media // Pediatrics. 2006. 118. (6). 2273-2279.
- Pociot F., Molvig J., Wogensen L. et al. A TaqI polymorphism in the human interleukin-1 beta (IL-1 beta) gene correlates with IL-1 beta secretion in vitro // Eur. J. Clin. Invest. 1992. (22). 396-402.
About Authors (Correspondence):
Bayke E.V. – candidate of medical sciences, assistant professor of chair for otolaryngology, e-mail: elenabayke@yandex.ru
Vitkovskiy Yu.A. – doctor of medical sciences, professor, head of chair of normal physiology, e-mail: yuvitkovsky@rambler.ru