The Siberian Scientific Medical Journal
№ 1 / 2017 / 32-40

Influence of combinations of pro-inflammatory and anti-inflammatory cytokine gene polymorphisms on the course of chronic purulent otitis media

Author Affiliations


The results of occurrence of polymorphism of genotypes inflammatory and anti- inflammatory cytokines IL-1β (С3953Т, Т511С, Т31С), IL-6 (С174G), IL-10 (G1082A, C592A, C819T), and TNF-α (G308A) in 299 patients with chronic purulent otitis media and 183 healthy individuals of Transbaikal region are presented. The high values of IL-1β (19.4 ± 0.23 pg/ml) (p < 0.05) and low numbers of IL-10 (12.5 ± 0.12 pg/ml) (p < 0.05) in carriers of gene high-producing inflammatory cytokines and of allele slow-producing anti-inflammatory cytokines in individuals with caries-destructive course of chronic purulent otitis media have been revealed. The reliable confirmation of IL-6 and TNF-α gene polymorphism aggravating effect on the course of chronic otitis have been received in the study.

Key words

genetic polymorphism, interleukins, chronic purulent otitis media, gene variants, Transbaikal region
About Authors (Correspondence):

Bayke E.V. – candidate of medical sciences, assistant professor of chair for otolaryngology, e-mail:

Vitkovskiy Yu.A. – doctor of medical sciences, professor, head of chair of normal physiology, e-mail:

Received: 15/02/2017