EXPERIMENTAL SUBSTANTIATION OF APPLICATION OF PEGYLATED INTERFERON α-2b ORAL FORMULATION FOR THERAPY OF ENTEROVIRAL INFECTION
Author Affiliations1Novosibirsk State Medical University of Minzdrav of Russia 630091, Novosibirsk, Krasny av., 52; Siberian Center of Pharmacology and Biotechnology 630090, Novosibirsk, Academik Lavrentiev av., 10
2Novosibirsk State Medical University of Minzdrav of Russia 630091, Novosibirsk, Krasny av., 52; Siberian Center of Pharmacology and Biotechnology 630090, Novosibirsk, Academik Lavrentiev av., 10
3State Research Center of Virology and Biotechnology «Vector»
4State Research Center of Virology and Biotechnology «Vector»
Abstract
The purpose of the work is the study of the antiviral activity and some pharmacokinetic parameters of oral formulation of pegylated interferon α-2b (PEG-IFN α-2b) obtained by technology of electron-beam synthesis. Material and Methods. The antiviral activity of PEG-IFN α-2b against Coxsackie virus was studied in RD cells culture. To study the pharmacokinetics we used FITC-labeled PEG-IFN α-2b. Results and Discussion. PEG-IFN α-2b has a specific activity comparable to the original interferon. Bioavailability of PEG-IFN α-2b is 29.68% in intragastric administration. The drug is detected in the intestinal tissue in a sufficiently high concentration.
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About Authors (Correspondence):
Kinsht D.N. – candidate of medical sciences, associate professor of the chair for pharmacology, clinical pharmacology and evidentiary medicine, е-mail: kinsht@scpb.ru
Full Text
Received: 28/06/2017
Accepted: 28/06/2017
