№ 4 / 2017 / 47-52

POSITIVE EFFECT OF IMMOBILIZED SUBTILISINS AT THE TREATMENT OF ESTROGEN-INDUCED CHRONIC VENOUS INSUFFICIENCY

Author: Emedova T.A.¹, Makarov K.Yu.², Madonov P.G.³, Sokolova T.M.⁴, Aydagulova S.V.⁵, Marinkin I.O.⁶

Abstract

Objective. To study the clinical efficacy of immobilized subtilisins in ten times dosage for the treatment of estrogen-induced chronic venous insufficiency (CVI) in women of reproductive age. Material and methods. 73 women
32,8 ± 2,9 years old with CVI occurred for the first time on the background of combined oral contraceptives. Women were treated by immobilized subtilisins in dose 800 units twice a day for 15 days. An observational study of the objective status was carried out before and after treatment using the VCSS scale, hemostasis, blood biochemical parameters and the ultrasound study of the small pelvic vessels. Results. The significant positive effect on objective status was revealed after treatment according to the modified VCSS scale. The decrease in the concentration of thrombinemia markers indices was revealed. Dopplerometry revealed an improvement in blood flow with stabilization of the vascular bed. Conclusion. Immobilized subtilisins are effective and safe for the treatment of chronic venous insufficiency and dishormonal thrombophilic status for women on the background of long-term combined oral contraceptives using.

Key words

Doppler analysis, immobilized subtilisins, сomplications of hormonal contraception, estrogen-induced chronic venous insufficiency

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About Authors (Correspondence):

Aydagulova S.V. – doctor of biological sciences, professor, head of the laboratory for cellular biology and fundamental basis of reproduction, e-mail: s.aydagulova@gmail.com

Full Text

snmzh_4-2017_emedova_i_dr_47-52.pdf

Received: 08/09/2017