EXPERIMENTAL STUDY OF IMMOBILIZED SUBTILYZINES INFLUENCE ON REPRODUCTIVE TOXICITY. I. ANTENATAL PERIOD
Author Affiliations1Novosibirsk State Medical University of Minzdrav of Russia
2Novosibirsk State Medical University of Minzdrav of Russia, 630091, Novosibirsk, Krasny av., 52
3Novosibirsk State Medical University of Minzdrav of Russia
4Goldberg Research Institute of Pharmacology and Regenerative Medicine
5Goldberg Research Institute of Pharmacology and Regenerative Medicine
6Goldberg Research Institute of Pharmacology and Regenerative Medicine
Abstract
The study of the possible embryotoxic properties of immobilized subtilisins realized in the antenatal period showed that its administration to female rats at a dose of 195 U / kg throughout the pregnancy period did not reveal toxic effects. At a dose of 1950 U / kg, the death of embryos after implantation increased, and the number of external hemorrhages, pathological changes in internal organs, and inhibition of ossification increased in living embryos.
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References
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About Authors (Correspondence):
Madonov P.G. – doctor of medical sciences, professor, head of department of for pharmacology, clinical pharmacology and evidentiary medicine, e-mail: madonov@scpb.ru
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