GASTROPROTECTIVE ACTION OF THE PEPTIDE COMPLEX FROM PIG KIDNEYS AT EXPERIMENTAL «INDOMETHACINE» ULCER IN RATS
Abstract
The aim of the study was a macro and microscopic evaluation of the structural state of the gastric mucosa under conditions of application of a peptide complex from the tissues of porcine kidneys with the experimental indomethacin-induced stomach ulcer. Experiments were carried out on 16 male Wistar rats divided equally into 2 groups: control (modeling gastric ulcer) and experimental (modeling gastric ulcer + introduction of the peptide complex from the tissues of porcine kidneys at a dose of 15 mg). The peptide complex was obtained by acetic acid extraction from a lyophilized dried pig kidney homogenate. The model of indomethacin damage to the gastric mucosa was reproduced by single intragastric administration of indomethacin at a dose of 60 mg/kg in 1 ml of physiological saline. It was established that in animals of the control group in the gastric mucosa the administration of indomethacin caused the phenomena of expressed erosive gastritis. Against this background, in the experimental group, there were definite signs of restoring the normal structure of the gastric mucosa. It turned out that in the experimental group, in comparison with the control of the disease, the number of strip-like erosions decreased 2.2 times, the Pauls index decreased by 3.6 times (for both p < 0.001). In addition, the average depth of erosion decreased by 85.6 % and the thickness of the gastric mucosa increased 1.2 times.
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ReferencesLorents S.E. – lecturer of the chair for pharmacology, e-mail: pharm_s@mail.ru
