ZINC AND ITS FRACTIONS LEVEL AS AN EARLY DIAGNOSTICS COMPONENT OF THE CHRONIC OBSTRUCTIVE LUNG DISEASE AT SMOKERS
Author Affiliations1Voronezh State Medical University n.a. N.N. Burdenko of Minzdrav of Russia 394036, Voronezh, Studencheskaya str., 10
2Voronezh State Medical University n.a. N.N. Burdenko of Minzdrav of Russia 394036, Voronezh, Studencheskaya str., 10
Abstract
Smoking is the main risk factor of respiratory tracts obstructive alterations pathophysiologically supported by zinc-containing enzymes. The aim of research was to investigate the zinc total content as well as its combined and free pools in persons with various smoking status and also with the normal and reduced function of external breath. Materials and methods. 30 patients with the verified diagnosis «chronic obstructive lung disease» and 90 healthy people have been examined in research of «event–control» type. The volume of forced expiration for the first second of the forced expiration action (VFE1) with the following estimation VFE1 index in percents of the norm as well as zinc and its fractions levels have been determined in spirometery The «combined zinc fraction ratio» indicator has been introduced to verify zinc participation in pathophysiological reactions with zinc containing enzymes. Results. Decrease in total zinc level in smokers with external breath reduced function as well as the significant increase in «combined zinc fraction ratio» indicator have been revealed in comparison with other groups. Conclussion. The received data allow using the zinc and its fractions level as the diagnostic criterion for early diagnosis of chronic obstructive lung disease.
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About Authors (Correspondence):
Shevtsova V.I. – assistant of the chair for polyclinic therapy and general medical practice, е-mail: shevVI17@yandex.ru
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