EXPERIMENTAL STUDY OF THE ACUTE TOXICITY OF THE ORAL FORM OF PEGYLATED INTERFERON α2-b
The aim of the study is to investigate the acute toxicity of the oral finished dosage form of pegylated interferon α-2b, obtained with the help of electron-beam synthesis technology. Material and methods. The preparation was orally administered to mice and rats at calculated therapeutic doses and doses exceeding them. Recorded parameters: animal death, general condition and behavior, weight of animals. Results and discussion. The drug has no toxic effect when administered orally. No macroscopic signs of gastric damage were found. The definition of LD is not possible.
About Authors (Correspondence):
Kinsht D.N. – candidate of medical sciences, associate professor of the chair for pharmacology, clinical pharmacology and evidentiary medicine, е-mail: firstname.lastname@example.org