The Siberian Scientific Medical Journal
 
 
№ 1 / 2018 / 17-21
DOI 10.15372/SSMJ20180103

PRECLINICAL STUDY OF THE TOXICITY OF THE ORAL FORM OF PEGYLATED INTERFERON α-2b UNDER ITS LONG-TERM USE

Author Affiliations

Abstract

The aim of the study is to investigate the chronic toxicity of the oral finished dosage form of pegylated interferon α-2b, obtained with the help of electron-beam synthesis technology. Materials and methods. The preparation was orally administered to rats and rabbits at the calculated therapeutic doses and doses exceeding them. The drug effect on the general condition and body weight, hematological parameters, myelogram, blood biochemical parameters, excretory and cardiovascular system, CNS were studied. As well as pathomorphological examination was carried out. Results and discussion. The drug has no toxic and locally irritating effect under its long-term use per os.

Key words

preclinical trials, interferon α-2b, pegylation, chronic toxicity, electron-beam immobilization
References
About Authors (Correspondence):

Madonov P.G. – doctor of medical sciences, professor, head of the chair for pharmacology, clinical pharmacology and evidentiary medicine, e-mail: madonov@scpb.ru

Full Text

Received: 25/02/2018
Accepted: 25/02/2018