PECULIARITIES OF BIOCHEMICAL INDICATOR VALUES IN PATIENTS WITH DORSOPATHY COMBINED WITH DISEASES OF THE HEPATOBILIARY SYSTEM

Author: Nikolaev Yu.A.¹, Savostyanova E.V.², Polyakov V.Ya.³

Abstract

Aim of the study was to investigate the features of biochemical indices in patients with spinal diseases combined with diseases of the hepatobiliary system (HBS). Material and methods. The examination of 46 patients with dorsopathy combined with diseases of the hepatobiliary system has been carried out. Results and discussion. It has been shown that the transnosological polymorbidity value in patients with DP combined with diseases of HBS was statistically significant increased in comparison with groups of patients with isolated diseases (spinal diseases, HBS). It was determined that the severity of the inflammatory process, as well as disturbances of the liver functions, was higher in case of combined pathology than in the presence of isolated forms of diseases. The changes in carbohydrate, lipid and purine metabolism being the factors of severity growth of the pathology course and risk factors for the development of diabetes mellitus, atherosclerosis and associated conditions are more pronounced in case of this combined pathology. That requires a personified approach to treatment and prevention of this category of patients. The results of the study can form the basis for the development of a new medical technology for assessing the severity of condition of patients with dorsopathy combined with diseases of the hepatobiliary system.

Key words

spinal diseases, diseases of the hepatobiliary system, biochemical indices

References

Belyalov F.I. Treatment of internal diseases in conditions of comorbidity. Irkutsk, 2014. [In Russian].

Chukhlovina M.L, Chukhlovin A.A. Diagnosis and treatment of dorsopathy in patients with connective tissue dysplasia. Zhurnal nevrologii i psikhiatrii imeni Sergeya Sergeevicha Korsakova = S.S. Korsakov Journal of Neurology and Psychiatry. 2017. (7). 43-46. [In Russian].

Grassi G., Seravalle G. Autonomic imbalance and metabolic syndrome: unraveling interactions, mechanisms and outcomes. J. Hypertens. 2006. 24. (1). 47-49.

Nikolaev Yu.A., Gevorgyan M.M., Kozaruk T.V., Kuznetsova A.P., Polyakov V.Ya. Features of clinical-biochemical and immunological indices in patients with hypertension, alien residents of the North, combined with diseases of the hepatobiliary system. Byulleten' Sibirskogo otdeleniya Rossiyskoy akademii meditsinskikh nauk = Bulletin of Siberian Branch of Russian Academy of Medical Sciences. 2012. (4). 66-71. [In Russian].

Nikolaev Yu.A., Mitrofanov I.M., Pospelova T.I., Dolgova N.A., Polyakov V.Ya. Features of polymorbidity in the modern clinic of internal diseases. Byulleten' Sibirskogo otdeleniya Rossiyskoy akademii meditsinskikh nauk = Bulletin of Siberian Branch of Russian Academy of Medical Sciences. 2014. 34(2) 44–49. [In Russian].

Nikolaev Yu.A., Sevost'yanova E.V., Mitrofanov I.M., Polyakov V.Ya., Dolgova N.A. Features of polymorbidity in patients of the therapeutic clinic of cardiological and gastroenterological profiles. Terapevticheskiy arkhiv = Therapeutic archive. 2016. (1). 40-45. [In Russian].

Oganov R.G. Vascular сomorbidity: general approaches to prevention and treatment. Ratsional'naya farmakoterapiya v kardiologii = Rational Pharmacotherapy in Cardiology. 2015. 11. (1). 4-7. [In Russian].

Pavlenko S.S. Pain in the lower back (epidemiology, clinical-diagnostic classification, modern directions in the diagnostics, treatment and standardization of medical care). Novosibirsk, 2007. [In Russian].

Savenkov M.P., Ivanova S.V. Hypertension in the pathology of the cervical part of the spine. Rossiyskiy kardiologicheskiy zhurnal = Russian journal of cardiology. 2012. (2). 38-44.

Schäfer I., Hansen H., Schön G., Höfels S., Altiner A., Dahlhaus A., Gensichen J., R-H. Steffi, W. Siegfried, A.B. Wolfgang, König H-H., von dem Knesebeck O., Wegscheider K., Scherer M., van den Bussche H., Wiese B. The influence of age, gender and socio-economic status on multimorbidity patterns in primary care. First results from the multicare cohort study. BMC Health Serv. Res. 2012. 12. 89.

Sergienko D.A., Bel'skaya G.N., Makarova L.D. Place of local injection therapy using symptom-modifying drugs in the treatment of back pain: a scientific review on the example of alflutop. Vestnik Chelyabinskoy oblastnoy klinicheskoy bol'nitsy = Bulletin of the Chelyabinsk regional clinical hospital. 2014. (2) 58–61. [In Russian].

Sevost'yanova E.V., Nikolaev Yu.A., Mitrofanov I.M., Polyakov V.Ya., Dolgova N.A. The role of risk factors for chronic non-infectious diseases in the development of polymorbid pathology. Klinicheskaya meditsina = Clinical medicine. 2017. 95. (8). 735-741. [In Russian].

Yakhno N.N. Pain: a practical guide for physicians. Moscow, 2011. [In Russian].

Zygmuntowicz M., Owczarek A., Elibol A., Chudek J. Comorbidities and the quality of life in hypertensive patients // Pol. Arch. Med. Wewn. 2012. 122. (7-8). 333-340.

About Authors (Correspondence):

Polyakov V.Ya. – doctor of medical sciences, leading researcher of laboratory for somatic diseases of medical ecological department, е-mail: vpolyakov15@mail.ru

Full Text

snmzh_2-2018_nikolaev_i_dr.pdf

Received: 26/04/2018

Accepted: 26/04/2018