FACTORS AFFECTING BONE REMODELING IN PATIENTS WITH HODGKIN’S LYMPHOMA (REVIEW)

Author: Voytko M.S.¹, Pospelova T.I.², Klimontov V.V.³, Mezit E.V.⁴

Abstract

Hodgkin’s lymphoma is considered a potentially curable disease. Chemotherapy-based salvage regimens can achieve responses in 90 % of patients with Hodgkin’s lymphoma. The possibility of achieving persistent disease-free survival poses a problem of ensuring a satisfactory quality of life and preventing the long-term consequences of antitumor therapy. One of those consequences may be a change in bone mineral density. Currently, a number of researchers have established that the risk of osteoporosis and osteopenia is highest in patients with Hodgkin’s lymphoma as compared to patients with other lymphoproliferative disorders. The decrease in bone mineral density can be associated with polychemotherapy including various combinations of cytostatic drugs and glucocorticoids, hypogonadism caused by toxic effects of radiotherapy and chemotherapy, tumor process, low physical activity and other factors. The high importance of the problem of osteoporosis is determined from social consequences - fractures of the vertebral bodies and fractures of the peripheral skeleton. That leads to economic risks in the health care area and causing a high level of disability. The aim of the study was to reveal the main regularities of bone remodeling in patients with Hodgkin’s lymphoma.

Key words

Hodgkin’s lymphoma, bone mineral density, osteoporosis, dual-energy X-ray absorptiometry, dual X-ray absorptometry

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About Authors (Correspondence):

Voytko M.S. – postgraduate student of the department of therapy, hematology and blood transfusion, e-mail: voytko.marie@yandex.ru

Full Text

snmzh_4-2018_voytko_i_dr.pdf

Received: 30/08/2018

Accepted: 30/08/2018