THE RESULTS OF INVASIVE TREATMENT OF PATIENTS WITH BRAIN ARTERIOVENOUS MALFORMATIONS WITH SEIZURE

Author: Krivoshapkin A.L.¹, Orlov K.Yu.², Brusyanskaya A.S.³, Sergeev G.S.⁴, Gaytan A.S.⁵, Simonovich A.E.⁶

Abstract

Purpose: to estimate influence of volume malformation on the course of structural epilepsy and neurophysiological data. Materials and methods: The study included 207 patients with brain AVM and seizure. 81 patients (pts) were performed by EEG before and after treatment. 103 patients underwent total invasive treatment, 96 pts – partial embolization and 8 pts – subtotal embolization. Follow up was 12 months. Evaluation of treatment was carried out on a scale Engel and ILAE. Results: Patients underwent a total treatment of grade I on the Engel scale were in 74.8 % (77 pts), and 1 grade on the ILAE scale were in 58.3 % (60 pts). Patients with a partial embolization of grade I on the Engel scale were in 40.4 % (42 pts), and 1 grade on the ILAE scale were in 20.2 % (21 pts), which is significantly worse than in the group with total treatment (on the Engel scale F = 5.1, ILAE – F = 5.8, р < 0.01). The subtotal embolization let get the grade I on the Engel scale in 62.5 % (5 pts). There was no significant difference to total treatment and partial embolization (p > 0.05). By EEG investigated: epileptic and slow-wave activity, focus on the hemisphere, where AVM is localized, disorganization and diffuse changes in bioelectric activity (BA). The BA improvement was in 17.1 % pts in the total treatment group, and in partial embolization group – in 2.5 % pts. However, these data were not significant different (p = 0.065). So, total treatment of brain AVMs gives the better control of seizure and more often improves EEG data.

Key words

arteriovenous malformation, structural epilepsy, neurophysiological study, seizure, EEG

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About Authors (Correspondence):

Brusyanskaya A.S. – neurologist of department of angonerology and neurosurgery, e-mail: asbr83@mail.ru

Full Text

snmzh_6-2018_krivoshapkin_145-153.pdf

Received: 18/12/2018

Accepted: 18/12/2018