A study of the dynamics of the activity of antioxidant ferments and lipids peroxidation effect of acrylamide in the isolated test- systems in vitro and in the pathogenesis of the acute intoxication
The direct action of acrylamide on the antioxidant ferments cell - catalase, superoxide dismutase, glutathione peroxidase in the subcellular preparations of different organs of rats leads first to the inhibition, and then to the increase in the activity of catalase and superoxide dismutase toward the end of the period of incubation, that can be the reason for the absence of lipids peroxidation effect during the addition of different concentrations of monomer to the postmitochondrial supernatant liquid of the liver of experimental animals. Stimulation of the lipids peroxidation effect was noted only as a result of the acute intoxication by poison in investigated organs.
About Authors (Correspondence):
Tarskikh M.M. – candidate of medical sciences, neurologist of the highest category, e-mail: firstname.lastname@example.org
Kolesnikov S.I. – counselor of the Presidium of SB RAMS, academician of RAMS