The Siberian Scientific Medical Journal
№ 5 / 2020 / 4-17
DOI 10.15372/SSMJ20200501

Genetics of «atopic march» syntropy

Author Affiliations


The study of the phenomenon of a combination of several diseases at the same time in an individual, actualized in the second half of the 19th century, is being actively analyzed 150 years later using genetic approaches. We present an overview of the results of such studies in relation to allergic diseases, in particular, a special variant, the so-called «atopic march», the sequential development of eczema, allergic rhinitis and asthma («atopic march» syntropy). The data of genetic and epidemiological studies were summarized, the analysis of genome-wide associative studies was carried out, and the role of mutations in the filaggrin gene (FLG) in the development of the «atopic march» syntropy was considered.

Key words

syntropy, comorbidity, «atopic march», syntropic genes (genes of comorbidity)
About Authors (Correspondence):

Bragina E.Yu., e-mail:

Full Text

Received: 28/10/2020
Accepted: 28/10/2020