Тромбоцитарные микровезикулы и их роль в обеспечении гемостатического потенциала (обзор литературы)
Реферат
В последние годы активно изучается роль микровезикул в передаче сигналов эндокринной системы, в обеспечении межклеточного взаимодействия, в переносе белков и нуклеиновых кислот из одной клетки в другую, в регуляции ангиогенеза, в воспалительных реакциях и в метастазировании опухолей. В данной публикации рассматриваются механизмы их образования, строение и потенциальное значение в качестве биологических маркеров. В числе фундаментальных реакций, связанных с микровезикулами, выделяется их прямое участие в обеспечении гемостатических реакций, направленных на остановку кровотечения при нарушении, в силу разных причин, целостности сосудистой стенки. Важная роль в этом отводится микровезикулам тромбоцитарного происхождения, что подтверждено рядом экспериментальных и клинических исследований. В обзоре оцениваются перспективы клинического применения одного из современных компонентов крови – криопреципитата – в качестве источника тромбоцитарных микровезикул.
Тэги
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Момот А.П., e-mail: xyzan@yandex.ru
