Localization of the receptors to leptin and adiponectin in skin and muscular tissue under nutrient deficiency of patients with chronic obstructive pulmonary disease
Author Affiliations1Vladivostok State Medical University 690002, Vladivostok, Ostryakov st., 2
2Vladivostok State Medical University 690002, Vladivostok, Ostryakov st., 2
3Vladivostok State Medical University 690002, Vladivostok, Ostryakov st., 2
4Vladivostok State Medical University 690002, Vladivostok, Ostryakov st., 2
Abstract
The immunocytochemical localization of leptin and adiponectin receptors in cells of skin, subcutaneous fat and muscular tissue, obtained through percutaneous thin needle biopsy of thigh of patients with chronic obstructive pulmonary disease with presentation of nutrient deficiency has been investigated. The 60 patients with chronic obstructive pulmonary disease of I, II, III stages and 20 healthy volunteers have been examined. It has been revealed that the receptors to adiponectin and leptin are presented in cells of skin, subcutaneous fat, vessels and cross-striated muscles of healthy volunteers. Contrariwise, the signals to adiponectin disappear in muscular tissue under chronic obstructive pulmonary disease, contrary to healthy target group; receptor activity to leptin significantly increases, and to adiponectin significantly decreases in other thigh tissues (p < 0.005). The imbalance in localization of receptors to adiponectins can be the indication of their participation in the development of nutrient deficiency under chronic obstructive pulmonary disease.
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About Authors (Correspondence):
Burtseva Ye.V. – postgraduate student, e-mail:katriness@list.ru
Nevzorova V.A. – doctor of medical sciences, professor, head of therapy department
Dyuizen I.V. – doctor of medical sciences, head of Central research laboratory
Kotsyurbiy E.A. – candidate of medical sciences, assistant professor of pathologic anatomy department
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