The Siberian Scientific Medical Journal
№ 6 / 2012 / 22-28

Prognostic criteria for preeclampsia on the data of maternal cardiac rhythm variability

Author Affiliations


In order to search for early prognostic criteria of preeclampsia (P) the measures of cardiac rhythm variability (CRV) were explored in 32 pregnants with afterwards P manifestation and 97 healthy women (H) with uncomplicated pregnancy at terms near 20 weeks of gestation. Dynamic characteristics of non-linear CRV (parameter of Detrended Fluctuation Analysis, DFA) were shown to be the most valuable signs for differentiation between P and H against mental (calculation in mind, Cal) and respiratory (deep breathing with a voluntary periodicity, Rsp) loading tests. Prominent DFA changes were found in P with initial autonomic disbalance: increase against parasympathetic prevalence (Cal: +33.6 %, p < 0.001; Rsp: +58.1 %, p < 0.001 in comparison with rest level) and decrease upon sympathetic predominance (Cal: –30.1 %, p < 0.001; Rsp: –8.2 %, p < 0.10). There were no such effects in H group. It has been concluded that changes of non-linear CRV under condition of mental and respiratory loading tests are the relevant criteria for prediction of preeclampsia at pre-clinical stage of its development.

Key words

pregnancy, heart rate variability, loading tests
About Authors (Correspondence):

Kleshchenogov S.А.candidate of medical sciences, senior researcher of the laboratory of physiology, e-mail:

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Received: 09/02/2015