The dependence of the functional status of the lymphatic drainage in the rat hind limb on the dosage and mode of ceftriaxone administration and the duration of chemotherapy

The dependence of the functional status of the lymphatic drainage in the rat hind limb on the dosage and duration of chemotherapy and the mode of ceftriaxone administration has been studied. It has been proved that the functional status of the lymphatic drainage in the hind limbs of rats really depends on the dosage and duration of chemotherapy and mode of administration of ceftriaxone. If ceftriaxone was administered intramuscularly to the maximum dose, then the suppression of the lymphatic drainage begins after 4 days of treatment, i.e. the lymphatic toxicity comes about. The drugs’ lymphatic toxicity should be considered when treating patients with the lymphostasis symptoms of any location. The lymphotropic introduction of ceftriaxone minimizes the lymphatic toxicity of this drug; moreover violation of the lymph drainage is minimal even at the highest concentrations and prolonged courses of antibiotic therapy.

Popov P.V. – candidate of medical sciences, police lieutenant colonel, specialist of professional training, e-mail: popov.pv@list.ru

Syropyatov B.Ya. – doctor of medical sciences, professor, head of the chair of general physiology and pathology

Odegova T.F. – doctor of medical sciences, professor, rector