Folate cycle and xenobiotic biotransformation system genes as markers of development risk of non-hodgkin malignant lymphomas in the residents of Novosibirsk
Author Affiliations1Novosibirsk State Medical University of Miszdrav of Russia 630091, Novosibirsk, Krasny av., 52
2Institute for Chemical Biology and Fundamental Medicine of SB RAS 630090, Novosibirsk, Akademic Lavrentiev av., 8
3Novosibirsk State Medical University of Miszdrav of Russia 630091, Novosibirsk, Krasny av., 52
4Institute for Chemical Biology and Fundamental Medicine of SB RAS 630090, Novosibirsk, Akademic Lavrentiev av., 8
Abstract
Changes in folate cycle and xenobiotic biotransformation system genes may cause the different susceptibility to non-Hodgkin's lymphomas (NHL). In the present study the association between seven single nucleotide substitutions in the folate cycle genes and deletions in genes of glutathione-S-transferase M1 and T1 (GSTM1 and GSTT1) with genetic risk of NHL was investigated. Association of 1958A-mutant allele with decreased aggressive lymphoma risk was revealed for polymorphic locus G1258A MTHFD1 (OR = 0.578, CI [0.415-0.805], p < 0.001). The combination of mutant 1420T alleles in homozygous T/T-genotype of SHMT1 gene may cause an increased aggressive lymphoma risk in 2.2 times (p < 0.02). The carriers of the mutant GSTM1 genotype have increased follicular lymphoma risk (OR = 1.96, CI [1.072-3.581], p < 0.02). Thus, these polymorphic variants may play a role in the pathogenesis of NHL and be used in non-Hodgkin's lymphomas diagnosis.
Key words
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About Authors (Correspondence):
Berezina O.V. - candidate of medical sciences, assistant of the chair for therapy, hematology and blood transfusiology, e-mail: ovberezina@mail.ru
Shadrina A.S. - senior assistant of the pharmacogenomic laboratory, e-mail: hamlet85@yandex.ru
Pospelova T.I. - doctor of medical sciences, professor, the head of the chair for therapy, hematology and transfusiology, e-mail: post_gem@mail.ru.
Filipenko M.L. - candidate of biological sciences, head of the pharmacogenomic laboratory, e-mail: max@niboch.nsc.ru
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