The therapeutic efficiency of mechanochemically synthesized Compositions of nano-structured particles of silicium dioxide and antibiotics at experimental sepsis in (CBA×C57Bl6)F1 mice
Author Affiliations11Institute of Clinical Immunology SB RAMS, 630099, Novosibirsk, Yadrintsevskaya str., 14
2Institute of Molecular Biology and Biophysics SB RAMS, 630117, Novosibirsk, Timakov str., 2
3Novosibirsk Interregional Veterinary Laboratory, 630007, Novosibirsk, Serebrennikovskaya str., 5
41Institute of Clinical Immunology SB RAMS, 630099, Novosibirsk, Yadrintsevskaya str., 14
51Institute of Clinical Immunology SB RAMS, 630099, Novosibirsk, Yadrintsevskaya str., 14
6Institute of Solid State Chemistry and Mechanochemistry SB RAS, 630128, Novosibirsk, Kutateladze str., 18
7Institute of Solid State Chemistry and Mechanochemistry SB RAS, 630128, Novosibirsk, Kutateladze str., 18
8Institute of Solid State Chemistry and Mechanochemistry SB RAS, 630128, Novosibirsk, Kutateladze str., 18
9Institute of Solid State Chemistry and Mechanochemistry SB RAS, 630128, Novosibirsk, Kutateladze str., 18
101Institute of Clinical Immunology SB RAMS, 630099, Novosibirsk, Yadrintsevskaya str., 14
Abstract
The therapeutic effi ciency of offi cinal forms of antibiotics mechanochemically modifi ed by sorption on nanostructured particles of silicium dioxide in comparison with their offi cinal forms on the model of experimental sepsis, induced by different strains of bacteria in (CBA×C57Bl6)F1 mice, has been studied. It has been shown that the application of these antibiotic compositions and nanostructured colloid nano-SiO2 allows considerably increasing animals` survival rate and intensity of system infl ammatory reaction. This testifi es to the expediency of using of the modifi cation of antibiotics for the enhancement of their therapeutic effi ciency at experimental sepsis.
Key words
References1. Dushkin A.V. Features of mechanochemical technology of organic synthesis and new materials // Khimiya v interesakh ustoychivogo razvitiya. 2004. (3). 251-274. (in Russian)
2. Ivanov D.V., Egorov A.M. Distribution and mechanisms of resistance of microorganisms, producing beta-lactamases // Biomeditsinskaya khimya. 2009. (1). 50-60. (in Russian)
3. Lazareva I.B., Igonin A.A. Actual questions of pharmacotherapy of sepsis and septic shock // Lechaschiy vrach. 2004. (4). 11-14. (in Russian)
4. Sidorenko S.V., Yakovlev S.V. Infections in the intensive care. M.: Bionika, 2003. 208 p. (in Russian)
5. Lyakhov N.Z., Grigorieva T.F., Barinova A.P., Vorsina I.A. Mechanochemical synthesis of organic compounds and composites with their participation // Uspekhi khimii. 2010. (3). 218-233. (in Russian)
6. Dushkin A.V., Meteleva E.S., Tolstikova T.G. et al. Mechanochemical synthesis and pharmacological activity of water-soluble complexes of arabinogalactan and drugs // Rus. Chem. Bul. 2008. (6). 1299-1307. (in Russian)
7. Gaidul K.V., Goldina I.A., Safronova I.V. et al. Comparative investigation of immunoactive and antibacterial properties of native and mechanically modified cefotaxim // Vestn. Ural’skoy med. academich. nauki. 2009. (2/1). 202–203. (in Russian)
8. Dushkin A.V. Mechanochemical synthesis of organic compounds and rapidly soluble materials // High-energy ball milling. Mechanochemical processing of nanopowders. Oxford: Woodhead Publishing Ltd., 2010. 249–273.
9. Seleem M.N., Munusamy P., Ranjan A. et al. Silica-Antibiotic hybrid nanoparticles for targeting intracellular pathogens // Antimicrob. Agents Chemother. 2009. 53. 4270–4274.
10. Slowing I.I., Vivero-Escoto J.L., Wu C.W., Lin V.C. Mesoporous silica nanoparticles as controlled release drug delivery and gene transfection carriers // Adv. Drug. Deliv. Rev. 2008. 60. 1278–1288.
11. Miyazaki S., Okazaki K., Tsuju M., Yamaguchi K. Pharmacodynamics of S-3578, a novel Cephem, in murine lung and systemic infection models // Antimicrob. Agents Chemother. 2004. 48. 378–383.
About Authors (Correspondence):
Gaidul K.V. – professor, leading researcher of immunopoiesis regulation laboratory, e-mail: kgaidul@mail.ru
Lykov A.P. – candidate of medical sciences, leading researcher of physical-chemical indication of immune processes laboratory, e-mail: lykovalex@freemail.ru
Larina O.N. – head of the bacteriological laboratory, e-mail: o.larina.72.@mail.ru
Goldina I.A. – researcher of immunopoiesis regulation laboratory, e-mail: igoldina@mail.ru
Safronova I.V. – candidate of medical sciences, researcher of immunopoiesis regulation laboratory, e-mail: safi v@freemail.ru
Gus’kov S.A. – engineer of organic compounds mechanochemistry group, e-mail: sergeyguskov@yandex.ru
Evseenko V.I. – candidate of chemical sciences, junior researcher of organic compounds mechanochemistry group, e-mail: evseenko@solid.nsc.ru
Dushkin A.V. – doctor of chemical sciences, head of organic compounds mechanochemistry group, e-mail: dushkin@solid.nsc.ru
Lyakhov N.Z. – corresponding member of RAS, director, e-mail: lyakhov@solid.nsk.su
Kozlov V.A. – academician RAMS, director, head of immunopoiesis regulation laboratory, e-mail: niiki01@online.nsk.su
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