The Siberian Scientific Medical Journal
 
 
№ 5 / 2012 / 28-32

Role of the transforming growth factor-β1 in structural changes of a bronchial wall at different variants of inflammation in bronchia

Author Affiliations

Abstract

The research aim was the evaluation of transforming factor of growth β1 influence on development of structural changes in mucous membrane of bronchial tubes at severe form of bronchial asthma and chronic obstructive lung disease. It has been determined by means of histological, immunohistological and morphometric methods, that the increase of level of the transforming factor of growth β1 in cells of bronchial epithelium with subepithelial fibrosis and thickening of basilar membranes were revealed at patients with severe therapeutecally resistant form of bronchial asthma of the phenotype «the asthma with the fixed bronchial obstruction», while the raised density of macrophages exposing receptors to the transforming growth factor β1 was found at patients with chronic obstructive lung disease, that is combined with expressed perivasculars fibrosis, squamous metaplasia of bronchial epithelium.

Key words

inflammation of the respiratory system, transforming growth factor β1, bronchial wall fibrosis
References
About Authors (Correspondence):

Gereng E.А. – candidate of medical sciences, senior researcher, assistant professor of the chair for morphology, e-mail: e-gereng@mail ru

Sukhodolo I.V. – doctor of medical sciences, professor, head of the chair for morphology, e-mail: suhodolo@sibmail.com

Pleshko R.I. – doctor of medical sciences, professor of the chair for morphology, e-mail: raisaP57@mail.ru

Ogorodova L.M. – doctor of medical sciences, professor, corresponding member of RAMS, honored worker of science, head of the chair of faculty pediatrics with the course f children diseases, e-mail: lm-ogorodova@mail.ru

Milto I.V.candidate of biological sciences, assistant professor of the chair for morphology,
e-mail: milto_bio@mail.ru

Bukreeva E.B. – doctor of medical sciences, professor of the chair for internal diseases of pediatric faculty,
e-mail: e-bukreeva@mail.ru

Kobyakova O.S. – doctor of medical sciences, head of the chair for general and medical practice
(family medicine), e-mail: olga_kobyakova@rambler.ru

Selivanovа P.A. – candidate of medical sciences, assistant of the chair for hospital therapy with the course
of physical rehabilitation and sports medicine, e-mail: p_selivanova@mail.ru

Kremis I.S. – doctor of pulmonological department, e-mail: kremanton@yandex.ru

Full Text

Received: 09/02/2015