The influence of myoglobinuric renal failure on nitric oxide syntheisis in rats

The daily urinary excretion of nitric oxide (NO) metabolites, renal tissue concentrations of arginine and of endogenous regulators of NO bioavailability (methylarginines) in myoglobinuric acute renal failure induced by glycerol were investigated. It has been shown that whole body NO synthesis is reduced in myoglobinuric ARF. The decreasing of renal tissue arginine and methylarginines content as well as the changing of their ratios with the predominance of NO synthase inhibitors contribute to the derangement of NO production in ARF.

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Sukhovershin R.A. – postgraduate student, the laboratory of adaptation processes regulation, e-mail: suhovershin@physiol.ru