The Siberian Scientific Medical Journal
№ 3 / 2012 / 34-38

The influence of myoglobinuric renal failure on nitric oxide syntheisis in rats

Author Affiliations


The daily urinary excretion of nitric oxide (NO) metabolites, renal tissue concentrations of arginine and of endogenous regulators of NO bioavailability (methylarginines) in myoglobinuric acute renal failure induced by glycerol were investigated. It has been shown that whole body NO synthesis is reduced in myoglobinuric ARF. The decreasing of renal tissue arginine and methylarginines content as well as the changing of their ratios with the predominance of NO synthase inhibitors contribute to the derangement of NO production in ARF.

Key words

arginine, methylarginine, nitrate, nitrite, nitric oxide, acute renal failure
About Authors (Correspondence):

Sukhovershin R.A. – postgraduate student, the laboratory of adaptation processes regulation, e-mail:

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Received: 10/02/2015