Hypocholesterinemic and antioxidant effect of the multicomponent plant remedy in hydrocortisone-induced dyslipoproteinemia

The pharmacotherapeutic effi cacy of multicomponent phytoremedy composed of the copies formulations of Tibetan medicine has been studied in the rats with hydrocortisone dyslipoproteinemia. It has been established that the induced dyslipoproteinemia accompanies by the increase in blood total cholesterol by 32 %, triacylglycerides (TG) by 40 %, atherogenic fraction lipoproteins very low density (VLDL) cholesterol by 33 % and low density lipoproteins (LDL) cholesterol by factor of 2,8, lower concentration of antiatherogenic high density lipoproteins (HDL) cholesterol by 13%. In addition, hydrocotisone-induced dyslipoproteinemia is accompanied by increased lipid peroxidation and decreased activity of endogenous antioxidant defense: the level of malondialdehyde (MDA) increased by 75 %, diene conjugates (DC) by 17 %, catalase activity was reduced by 54 %. Course preventive medication with phytopreparations decreases the blood total cholesterol by 20 %, TG by factor of 2,1, atherogenic fraction VLDL by factor of 2, LDL by 45 %, partly contributes to increased concentration of antiatherogenic HDL fraction. Additionally, the remedy inhibits the processes of free radical oxidation of lipids – reduces the level of MDA by 40 %, DC by 28 % and increases the activity of antioxidant enzymes – catalase in blood serum by 52 %.

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Banzaraksheev V.G. – candidate of medical sciences, senior researcher of laboratory of experimental pharmacology of department of biological active substances, e-mail: gambalovi4@mail.ru