The Siberian Scientific Medical Journal
 
 
№ 3 / 2014 / 13-17

The investigation of cystatin C and cystatin SN as possible markers of eye tumor development in biological fluids

Author Affiliations

Abstract

Objectives: to investigate the possible role of cystatin C and cystatin SN as potential biomarkers of eye tumor development in eye biological fluids locally and in serum. Serum, tear fluid and intraocular fluid samples obtained from the anterior chamber of eyes in patients with choroidal melanoma, pseudotumor form of age-related macular degeneration , and healthy volunteers were studied by enzyme immunoassay method. The increase of cystatin C concentration and the decrease of cystatin SN concentration were revealed in all biological fluids of examined patients: both with melanoma of the choroid and with age- macular degeneration.

Key words

intraocular fluid, choroidal melanoma, tear, cystatin SN, cystatin C
References
About Authors (Correspondence):

Dikovskaya M.A. – ophthalmologist, head of the department for ophthalmology, e-mail: dikovskayam@mail.ru

Trunov A.N. – doctor of medical sciences, professor, deputy director for scientific work, head of the laboratory of immunology, e-mail: trunov1963@yandex.ru

Kuleshova O.N. – doctor of medical sciences, professor, ophthalmologist

Loktev K.V. – researcher

Chernykh V.V. – doctor of medical sciences, professor, director, e-mail: rimma@mntk.nsk.ru

Aftanas L.I. – academician of RAS, director

Korolenko T.A. – doctor of medical sciences, professor, head of the laboratory, e-mail: t.a.korolenko@physiol.ru

Full Text

Received: 09/02/2015