The Siberian Scientific Medical Journal
№ 4 / 2012 / 32-36

Cyclophosphamide administration for limitation of carcinosarcoma Walker 256 growth in rats aggravates the paraneoplastic ultractructural disturbances in the liver

Author Affiliations


The signs of lysis and necrobiosis intensification in parenchyma and stroma cells were revealed in the liver of carcinosarcoma Walker 256-bearing rats at the 7th day after cyclophosphamide administration. Compensatory and adaptive reconstructions and apoptosis were noted in part of cell as a result of cyclophosphamide cytostatic effect. Combined effects of paraneoplastic factors and cyclophosphamide enhance subcellular sinusoidal obstructive syndrome manifestation caused by cyclophosphamide. Hepatocytes ultrastructural features reflect the functional liver response via triggering of detoxification mechanisms in hepatocytes with extensive smooth endoplasmatic reticulum.

Key words

carcinosarcoma Walker 256, liver, ultrastructure, cyclophosphamide
About Authors (Correspondence):

Efremov A.V. ─ doctor of medical sciences, professor, Corresponding Member of RAMN, head of the chair of pathophysiology, honored scientist of the RF

Kunts T.A. ─ researcher of Central Research Laboratory, e-mail:

Ovsyanko E.V. ─ candidate of medical sciences, associated professor of the chair of anatomy, histology, biology

Ishenko I.Yu. ─ candidate of biological sciences, researcher of Central Research Laboratory

Pustovetova M.G. ─ doctor of medical sciences, professor, head of Central Research Laboratory

Full Text

Received: 10/02/2015