Combined administration of the atorvastatin and antioxidant coenzyme Q10 at metabolic syndrome

The dynamics of the glucose-insulin homeostasis condition and lipoperoxidation processes in patients with metabolic syndrome against the administration of the atorvastatin and its combination with coenzyme Q₁₀ have been investigated. It is found out that atorvastatin depresses antioxidant system, as well as stimulates the increase of insulin resistance at metabolic syndrome. Atorvastatin and coenzyme Q₁₀ combined therapy improves antioxidant defense that results in leveling of intensification of the free radical lipid oxidation, induced by the administration of statin, as well as exerts no negative influence on the carbohydrate metabolism condition in patients with metabolic syndrome. The aforesaid finding proves the expediency of administration of coenzyme Q₁₀ with statin therapy

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