The Siberian Scientific Medical Journal
№ 4 / 2012 / 45-51

Combined administration of the atorvastatin and antioxidant coenzyme Q10 at metabolic syndrome

Author Affiliations


The dynamics of the glucose-insulin homeostasis condition and lipoperoxidation processes in patients with metabolic syndrome against the administration of the atorvastatin and its combination with coenzyme Q10 have been investigated. It is found out that atorvastatin depresses antioxidant system, as well as stimulates the increase of insulin resistance at metabolic syndrome. Atorvastatin and coenzyme Q10 combined therapy improves antioxidant defense that results in leveling of intensification of the free radical lipid oxidation, induced by the administration of statin, as well as exerts no negative influence on the carbohydrate metabolism condition in patients with metabolic syndrome. The aforesaid finding proves the expediency of administration of coenzyme Q10 with statin therapy

Key words

antioxidants, metabolic syndrome, lipid peroxidation, statins
About Authors (Correspondence):

Yubitskaya N.S. – candidate of medical sciences, researcher of laboratory of rehabilitative treatment,

Antonyuk M.V. – doctor of medical sciences, head of the laboratory of rehabilitative treatment,


Yan’kova V.I. – candidate of biological sciences, scientific secretary, e-mail:

Full Text

Received: 10/02/2015