The Siberian Scientific Medical Journal
№ 5 / 2012 / 48-54

Pathogenesis of chronic renal failure in patients with hypertension (review)

Author Affiliations


Pandemia of chronic kidney disease (CKD) is stated in the world over the past decade. The significant role in the widespread increase of the CKD prevalence plays the growing proportion of the kidneys vascular lesions (renal vasculopathy) in the structure of nephrological diseases. The endothelial dysfunction and remodeling of intrarenal vessels are the basis for hypertensive renal disease forming. Early markers of cardiac involvement correlate with the initial manifestations of renal involvement. The appearance and progression of changes in heart and kidney are largely determined by similar hemodynamic, neurohumoral and genetic mechanisms.

Key words

arterial hypertension, risk factors for target organs damage, chronic renal failure
About Authors (Correspondence):

Nikolaev K.Yu. – doctor of medical sciences, professor, chief researcher, e-mail:

Nikolaeva A.A. – doctor of medical sciences, professor, chief researcher, e-mail:

Popova L.V. – doctor of medical sciences, head of therapy department

Ovsyannikova A.K. – postgraduate student, e-mail:

Lifshits G.I. – doctor of medical sciences, professor, head of laboratory of personalized medicine,

Gicheva I.M. – candidate of medical sciences, chief medical officer, е-mail:

Full Text

Received: 10/02/2015