Activity of the local inflammatory processes in the pathogenesis of the infertility in women with chronic inflammation of the reproductive system
Author Affiliations1Institute of Clinical and Experimental Lymphology of SB RAMS 630117, Novosibirsk, Timakov str., 2
2Novosibirsk State Medical University of Minzdrav of Russia 630091 , Novosibirsk, Krasny av., 52
3Novosibirsk State Medical University of Minzdrav of Russia 630091 , Novosibirsk, Krasny av., 52
4Novosibirsk State Medical University of Minzdrav of Russia 630091 , Novosibirsk, Krasny av., 52
5Research Center of Clinical and Experimental Medicine of SB RAMS, 630117, Novosibirsk, Timakova str., 2
6Research Center of Clinical and Experimental Medicine of SB RAMS, 630117, Novosibirsk, Timakova str., 2
7Institute of Clinical and Experimental Lymphology of SB RAMS 630117, Novosibirsk, Timakov str., 2
8Institute of Clinical and Experimental Lymphology of SB RAMS 630117, Novosibirsk, Timakov str., 2
Abstract
The aim of the study was to investigate the activity of a local inflammatory process and the immune response in women of reproductive age with infertility and chronic inflammatory diseases of reproductive areas in clinical remission. The content of TNF-?, IL-4, IL-6, IL-10, IFN-?, MCP-1, circulating immune complexes in the peritoneal fluid was determined. It has been revealed that in the mechanisms of infertility arising amid chronic inflammatory disease of reproductive sphere important role plays activation the local inflammatory process, as evidenced by the significant increase in the concentrations of biological substances with pro-inflammatory activity (TNF-?, IL-6, MCP-1), inducers of an immune response (IL-4 and IFN-?), markers of cellular destruction, autoantibodies to antigens of native DNA and levels of the integral index of activation of humoral immune system - circulating immune complexes in peritoneal fluid. The activation of the local immuno-inflammatory process in clinical remission of chronic inflammatory disease of reproductive sphere is a significant factor in the emergence and development of infertility.
Key words
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About Authors (Correspondence):
Trunov A.N. - doctor of medical sciences, professor, head of the laboratory of immunology of reproduction, e-mail: trunov1963@yandex.ru
Marinkin I.O. - doctor of medical sciences, professor, head of the chair of obstetrics and gynecology, e-mail: reсtorngmu@yandex.ru
Kuleshov V.M. - doctor of medical sciences, professor of the chair of obstetrics and gynecology, e-mail: kuleshov_vm@mail.ru
Gorbenko O.M. - candidate of biological sciences, senior researcher, e-mail: trunov1963@yandex.ru
Shvayuk A.P. - candidate of biological sciences, senior researcher, e-mail: trunov1963@yandex.ru
Obukhovа О.О. - doctor of medical sciences, leading researcher, e-mail: trio188@yandex.ru
Vaulin D.E. - obstetrician-gynecologist, postgraduate student of the chair for obstetrics and gynecology, e-mai: kuleshov_vm@mail.ru
Trunova L.A. - doctor of medical sciences, professor, corresponding member of RAMS, chief researcher of the laboratory of immunology of reproduction, e-mail: trunov1963@yandex.ru
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