The Siberian Scientific Medical Journal
 
 
№ 3 / 2014 / 61-66

Imbalance content of the cytokines and growth factors in vitreous from patients with proliferative diabetic retinopathy

Author Affiliations

Abstract

32 samples of vitreous of patients with proliferative diabetic retinopathy and traction retinal detachment and 25 samples of vitreous of patients with traction retinal detachment (control) were investigated. The concentrations of vascular endothelial growth factor, pigment epithelium-derived factor, monocyte chemotactic protein-1, and interleukin 4, 6, 8, 10, 17A in the vitreous were studied. The significant increase in the concentrations of vascular endothelial growth factor, pigment epithelium-derived factor, IL-17A, IL-8, IL-6, MCP-1, IL-4 in the vitreous of patients with proliferative diabetic retinopathy were revealed. The study showed that the important role in the mechanisms of development of proliferative diabetic retinopathy plays the activity of vascular proliferation and local immuno-inflammatory process. Identified correlations testify to the relationship of these processes.

Key words

proliferative diabetic retinopathy, vitreous, growth factors, cytokines
References
About Authors (Correspondence):

Chernykh V.V. – doctor of medical sciences, professor, director, e-mail: rimma@mntk.nsk.ru

Trunov A.N. – doctor of medical sciences, professor, deputy director on scientific work, e-mail. trunov1963@yandex.ru

Varvaranskiy Ye.V. – ophthalmologist, e-mail: rimma@mntk.nsk.ru

Smirnov E.V. – candidate of medical sciences, ophthalmologist, e-mail: rimma@mntk.nsk.ru

Chernykh D.V. – ophthalmologist, e-mail: rimma@mntk.nsk.ru

Obukhova О.О. – doctor of medical sciences, leading researcher, e-mail: trio@yandex.ru

Gorbenko O.M. – candidate of biological sciences, senior researcher, e-mail: trunov1963@yandex.ru

Shvayuk A.P. – candidate of biological sciences, senior researcher, e-mail: trunov1963@yandex.ru

Full Text

Received: 09/02/2015