Tactics of therapy in chronic myeloid leukemia during pregnancy. Clinical case
Abstract
A case of a successful pregnancy outcome in a patient with chronic phase of chronic myeloid leukemia has been provided. The need to choose a therapy during pregnancy was the particularity of the case. The increasing of the leukemic cell mass evaluated by quantitative method of real-time polymeraze chain reaction (expression of chimeric oncogene BCR-ABL) has been observed at the moment of pregnancy diagnostics and during further monitoring. Since the 2nd trimester of pregnancy the patient was treated by imatinib. BCR-ABL transcript level rapidly decreased and a complete molecular remission was achieved at high tolerability. A healthy child was born at the 37th week of pregnancy. The approaches to therapy tactics of chronic myeloid leukemia during pregnancy have been discussed.
Key words
ReferencesChelysheva E.Yu. – candidate of medical sciences, senior researcher of scientific and consultative department of myeloproliferative disorders, e-mail: denve@bk.ru
Turkina A.G. – doctor of medical sciences, professor, head of scientific and consultative department of myeloproliferative disorders, e-mail: turkianna@yandex.ru
Polushkina E.S. – candidate of medical sciences, researcher of obstetric physiological department, e-mail: epolushkina@mail.ru
Shmakov R.G. – doctor of medical sciences, head of obstetric physiological department, e-mail: mdshmakov@mail.ru