Association of single nucleotide polymorphisms of gene GPC5, CASQ2, NOS1AP, GPD1L with sudden cardiac death in russian population
Author Affiliations1Novosibirsk State Medical University of Minzdrav of Russia 630091, Novosibirsk, Krasny av., 52
2Institute of Internal and Preventive Medicine of SB RAMS 630089, Novosibirsk, Boris Bogatkov str., 175/1
3Institute of Internal and Preventive Medicine of SB RAMS 630089, Novosibirsk, Boris Bogatkov str., 175/1, Institute of Cytology and Genetics of SB RAS 630090, Novosibirsk, Akademic Lavrentev av., 10
4Institute of Cytology and Genetics of SB RAS, 630090, Novosibirsk, Prospekt Akademik Lavrentyev, 10; Institute of Internal and Preventive Medicine of SB RAMS, 630089, Novosibirsk, Boris Bogatkov str., 175/1
5Novosibirsk State Medical University of Minzdrav of Russia 630091, Novosibirsk, Krasny av., 52, Novosibirsk Regional Bureau of Forensic Medicine Novosibirsk, 630087, Nemirovich-Danchenko str., 134
6Institute of Cytology and Genetics of SB RAS, 630090, Novosibirsk, Prospekt Akademik Lavrentyev, 10; Institute of Internal and Preventive Medicine of SB RAMS, 630089, Novosibirsk, Boris Bogatkov str., 175/1
Abstract
Study objective. To investigate the association of rs3864180 gene GPC5, rs3010396 gene CASQ2, rs10918859 gene NOS1AP, rs9862154 gene GPD1L region with sudden cardiac death in the Russian population. Material and methods. A group of individuals who died of sudden cardiac death (n = 352), the control group matched by age and sex (n = 195), a group of teenagers (n = 297). The statistically significant differences between the groups were not found by the frequencies of genotypes and alleles of rs10918859 gene NOS1AP, rs9862154 gene GPD1L region. The statistically significant differences between the group of men who died of sudden cardiac death and the control group (OR = 0.4, 95 % CI 0.2-0.8, р = 0.020; OR = 0.4, 95 % CI 0.2-0.7, р = 0.006, respectively) were revealed by the frequencies of genotypes of rs3864180 gene GPC5, rs3010396 gene CASQ2. rs3864180 gene GPC5 and rs3010396 gene CASQ2 are associated with sudden cardiac death in men in the Russian population.
Key words
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About Authors (Correspondence):
Maksimov V.N. - doctor of medical sciences, head of laboratory for molecular genetic studies of therapeutic diseases, e-mail: medik11@mail.ru
Ivanova A.A. - attending physician, e-mail: ivanova_a_a@mail.ru
Orlov P.S. - junior researcher, e-mail: dinara2084@mail.ru
Ivanoshchuk D.Y. - junior researcher, e-mail: dinara2084@mail.ru
Savchenko S.V. - doctor of medical sciences, professor of forensic medicine
Voevoda M.I. - doctor of medical sciences, professor, corresponding member of RAMS, director, e-mail: mvoevoda@ya.ru
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