Treatment of feet`onychomycosis caused by Trichophyton rubrum at the HIV-infected patients

Objective: to study the effectiveness of fluconazole and terbinafine in the treatment of onychomycosis of feet caused by T. rubrum in HIV-infected patients. Materials and methods. The study included 24 HIV-infected patients with mycologically confirmed feet` onychomycosis caused by T. rubrum. Patients were divided into two groups: fluconazole of 150 mg was used once a week in group 1 (n = 14), terbinafine of 250 mg per day - in the 2nd group (10 patients). Results. Duration of treatment ranged from 3 to 9 months. The clinical and mycological cure occurred only 30 % of patients in both groups after 3-4 months of therapy. The treatment duration was 9.5 months in 70 % of patients. For the use of fluconazole the clinical and mycological cure was seen in 85.7 % (12/14) of patients, for terbinafine - in 90 % (9/10) (p > 0,05). The severe side effects and drug interactions have not been registered in both groups. Conclusions. The long-term (3-9 months) use of fluconazole and terbinafine was effective and safe in HIV-infected patients with feet` onychomycosis caused by T. rubrum. The larger randomized study is required to determine the drug of choice.

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Raydenko O.V. - dermatologist, e-mail: olgaray2007@rambler.ru
Klimko N.N. - doctor of medical sciences, professor, head of the chair of clinical mycology, allergology and immunology, e-mail: n_klimko@mail.ru