The Siberian Scientific Medical Journal
 
 
№ 5 / 2014 / 17-21

Molecular-cellular mechanisms of pulmonary fibrosis and spontaneous pneumothorax

Author Affiliations

Abstract

Fibrosis along with inflammation as the typical pathological processes is the most lung diseases basis. Molecular biological mechanisms underlying the progression of fibrosis in lung tissue are under the process of evaluating and studying. Experiments conducted in vitro and in animal models have confirmed the presence of pulmonary fibrosis inducers. Application of the data can be performed in clinical practice, including managing of lung tissue transformation in spontaneous pneumothorax and bullous lung disease.

Key words

homocysteine, nitric oxide, spontaneous pneumothorax, transforming growth factor beta, lung fibrosis, endothelin-1
References
About Authors (Correspondence):

Pustovetova M.G. – doctor of medical sciences, professor of pathophysiology and clinical pathophysiology chair, head of the central research laboratory, e-mail: patophisiolog@mail.ru.

Chikinev Yu.V. – doctor of medical sciences, professor, head of hospital and children’s surgery chair, e-mail: chikinev@inbox.ru

Piontkovskaya K.A. – postgraduate student of pathophysiology and clinical pathophysiology chair, e-mail: kristinapiontkovskaya@gmail.com

Drobyazgin E.A.doctor of medical sciences, associate professor of hospital and children’s surgery chair, e-mail: evgenyidrob@yandex.ru

Full Text

Received: 08/02/2015