Disorders of blood coagulation final stage in children with hematomezenhimal dysplasia syndrome under conditions of background surgical pathology
Author Affiliations1 Irkutsk State Regional Children’s Clinical Hospital 664022, Irkutsk, Gagarin av., 4
2 Novosibirsk State Medical University of Minzdrav of Russia 630091, Novosibirsk, Krasny av., 52
3Novosibirsk State Medical University Minzdrava Russia 630091, Novosibirsk, Krasnyi av., 52
Abstract
The results of studies of the final stage of blood clotting syndrome in children with systemic mesenchymal dysplasia (SMD) on the background of surgical pathology have been presented. Most of changes are associated with the presence of abnormal circulating fibrinogen (dysfibrinogenemias). It has been revealed that hemorrhagic and thrombotic manifestations of SMD are at high risk of intra-and postoperative complications and require adequate preoperative verification and pathogenetic correction. The carrier frequency of thrombophilic DNA-polymorphisms in patients with systemic mesenchymal dysplasia has been investigated
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About Authors (Correspondence):
Firsova L.V. – haematologist of department of oncology, e-mail: meveto@mail.ru
Sturov V.G. – doctor of medical sciences, hematologist, e-mail: sturov@mail.ru
Kovynev I.B. – doctor of medical sciences, professor of the chair hematology, transfusion and therapy, e-mail: kovin-gem@mail.ru
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