Disorders of blood coagulation final stage in children with hematomezenhimal dysplasia syndrome under conditions of background surgical pathology

The results of studies of the final stage of blood clotting syndrome in children with systemic mesenchymal dysplasia (SMD) on the background of surgical pathology have been presented. Most of changes are associated with the presence of abnormal circulating fibrinogen (dysfibrinogenemias). It has been revealed that hemorrhagic and thrombotic manifestations of SMD are at high risk of intra-and postoperative complications and require adequate preoperative verification and pathogenetic correction. The carrier frequency of thrombophilic DNA-polymorphisms in patients with systemic mesenchymal dysplasia has been investigated

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