The assessment of hemocoagulation disorders and immune mechanisms of their regulation at hemorrhagic fever with renal syndrome in region of circulation of several serotypes of hantaviruses

Hemorrhagic disorders, especially the «phenomenon of thrombocytopenia», are typical and, at the same time, unknown syndrome in hemorrhagic fever with renal syndrome (HFRS). The aim: to study the role of IL-17 in the pathogenesis of gemocoagulation disorders in hemorrhagic fever with renal syndrome in the course of the disease. Materials and methods: a comprehensive clinical and laboratory examination of 60 patients with hemorrhagic fever with renal syndrome, taking place in infectious hospitals of Vladivostok in 2008–2012 has been done. Results: a significant increase IL-17 in serum of patients with HFRS, associated with different serotypes of hantavirus, which correlates with the level of platelets in peripheral blood are revealed. Also the significant increase in the concentration of soluble fibrin-monomer complexes in the patients serum whith the other unchanged rates of the haemostatic system.

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Slonova R.A.  – head of the laboratory of HFRS, e-mail: slonova@inbox.ru