The urchin bioactive substances – framework for drugs and pharmaceutical materials development
Abstract
The current understanding of the biological activity of the gonads of sea urchins and metabolites derived from these marine invertebrates are presented in this review. It has been shown that they have antioxidant, anti-inflammatory, antihyperlipidemic, antitumor and antibacterial effects. The materials on the original medications developed by the Far East scientists on the basis of quinoid pigments of sea urchins are represented. The prospects for new drugs and dietary supplements based on echinoderms metabolites and the possibility of extending the «Histochrome» applicable scope at other nosologic forms have been discussed.
Key words
1. Artyukov A.A., Popov A.M., Tsybulsky A.V. et al. Pharmacological activity echinochrome A separately and as part of the BAA "Timarin" // Biomeditsinskaya khimiya. 2012. 58. (3). 281–290. (in Russian)
2. Besednova NN, Epstein LM. Natural modifier functions of innate immunity (the DNA of Pacific salmon roe). Vladivostok: Meditsina DV, 2010. 192 p. (in Russian)
3. Besednova N.N., Zaporozhets T.S., Makarenkova I.D. et al. Sulfated polysaccharides algae modifiers function of innate immunity in bacterial, viral and parasitic diseases // Uspekhi sovremennoy biologii. 2011. 131. (5). 503–517. (in Russian)
4. Besednova N.N., Zaporozhets T.S. New innate immunity receptor agonists from marine aquatic // Zhurnal mikrobiologii, epidemilogii i immunobiologii. 2011. (5). 98–106. (in Russian)
5. Vareshin NA. Effects of electromagnetic fields and some substances during early embryogenesis of sea urchins: abstract of thesis … candidate of biological sciences. Vladivostok, 2008. (in Russian)
6. Gusev M.R., Beslaneeva M.B. Clinical evaluation of the effectiveness of national antioxidant drug "histochrome" // Zhurnal oftal'mologii. 2010. (3). 37–39. (in Russian)
7. Danilenko S.A. Regulation of free radical processes and apoptosis during oxidative stress: abstract of thesis … candidate of biological sciences. Rostov-on-Don, 2012. (in Russian)
8. Derjaguina V.P., Ryzhov N.I., Ilnitsky A.P. et al. Natural antioxidant action echinochrome on growth subcutaneously implanted Ehrlich adenocarcinoma // Rossiyskiy onkologicheskiy zhurnal. 2005. (3). 32–36. (in Russian)
9. Zadorozhnyy P.A. Influence of the environment and the state of the organism to the content of carotenoids in sea urchins: abstract of thesis … candidate of biological sciences. Vladivostok, 2003. (in Russian)
10. Internet site: http://www. tumorres.com/tumor-stem-cell/699.htm. (in Russian)
11 Kozlov V.K., Kozlov M.V., Lebedko O.A. et al. Clinical and experimental validation of echinochrome A for correction and prevention of structural and metabolic abnormalities in the respiratory system in the early stages of ontogeny // Dal'nevostochnyy meditsinskiy zhurnal. 2009. (2). 58–61. (in Russian)
12. Kozlov V.K., Kozlov M.V., Guseva O.E. Antioxidant activity of echinochrome A in chronic inflammatory lung diseases in children // Tikhookeanskiy meditsinskiy zhurnal. 2009. (3). 106–107. (in Russian)
13. Kozlov V.K., Kozlov M.V., Lebedko O.A. et al. Influence of echinochrome A on some parameters of the system of free status and T cell immunity in children with chronic inflammatory lung diseases in remission // Dal'nevostochnyy meditsinskiy zhurnal. 2010. (1). 55–58. (in Russian)
14. Kostecki E.Y., Velansky P.V., Sanin N.M. Phospholipids are the organs and tissues of echinoderms and tunicates Peter the Great Bay (Sea of Japan) // Biologiya morya. 2012. 38. (1). 65–71. (in Russian)
15. Krivoshapko O.A., Popov A.M. Curative and preventive properties of lipids and antioxidants isolated from marine aquatic // Voprosy pitaniya. 2011. (2). 4–8. (in Russian)
16. Kryzhanovsky S.P., Yatskov M.A., Golovacheva V.D. Hypolipidemic effect of food supplements from the eggs of sea urchins in the monotherapy and combination with atorvastatin // Tikhookeanskiy meditsinskiy zhurnal. 2012. (1). 29–31. (in Russian)
17. Lebskaya T.K., Shapovalova L.A. Biochemical features of the Barents Sea urchin Strongylocentrotus droebachiensis and aspects of its processing. Murmansk, 2008. 146 p. (in Russian)
18. Mishchenko N.P., Fedoreev S.A., Dogadova L.P. Drug histochrome for ophthalmology // Vestnik Dal'nevostochnogo otdeleniya Rossiyskoy akademii nauk. 2004. (3). 111–119. (in Russian)
19. Mishchenko N.P., Fedoreev S.A., Gusev E.I. et al. The influence of histochrome on the dynamics of neurological disorders and MRI picture in experimental hemorrhagic stroke // Zhurnal nevrologii. Insul't. 2005. (15). 61–66. (in Russian)
20. Patent 2134107 RF. The drug "histochrome" for treatment of inflammatory diseases of the retina and cornea / Elyakov G.B., Maximov O.B., Mishchenko N.P. et al., published 10.08.99. (in Russian)
21. Patent 2340216 RF. Biologically active food supplement and a method for obtaining / Artyukov A.A., Glazunov V.P., Kozlovskaya E.P., published 10.12.08. (in Russian)
22. Patent 2366413 RF. The method of rehabilitation of patients after cosmetic surgery / Bratko V.I., Atamanov V.V., Kulakov A.V., published 10.09.09. (in Russian)
23. Patent 2375710 RF. Way to determine the ecological status of the territories in the strontium / Tyutikov S.F., Ermakov V.V., published 25.09.08. (in Russian)
24. Patent 2396244 RF. A method of producing purpurogallin / Artyukov A.A., Makhan'kov V.V., Kupera E. et al., published 10.08.10. (in Russian)
25. Popov AM. Biological activity and mechanism of action of secondary metabolites from terrestrial plants and marine invertebrates: abstract of thesis … doctor of biological sciences. Vladivostok, 2003. (in Russian)
26. Priezzheva E.J., Lebedko O.A., Ryzhavsky B.J., Kozlov V.K. Influence of echinochrome on free radical oxidation processes in the kidney 40-day-old albino rats exposed prenatally exposed lead nitrate // Zdorov'ye. Meditsinskaya ekologiya. Nauka. 2009. (4–5). 39–40. (in Russian)
27. Rodkina S.A., Chen B. Effect of temperature as a factor of the medium on the composition of lipids and fatty acids in the gonads of the sea urchin Strongylocentrotus nudus // Izvestiya TINRO. 2007. (148). 289–296. (in Russian)
28. Solov'yev A.Y., Morozova P.Yu., Chernova I.A. et al. Extraction and activity of regulatory peptides from sea urchin eggs // Pharm. Chem. J. 2011. 44. (11). 601–603. (in Russian)
29. Stonik V.A. The study of natural compounds in TIBOH FEB RAS // Vestnik Dal'nevostochnogo otdeleniya Rossiyskoy akademii nauk. 2005. (4). 138–144. (in Russian)
30. Stonik V.A., Tolstikov G.A. Natural compounds and creation of medicinal drugs // Vestnik Dal'nevostochnogo otdeleniya Rossiyskoy akademii nauk. 2008. 78. (8) .675–687. (in Russian)
31. Khalfina T.N. Clinical and pathogenetic aspects of visceral manifestations of gout: abstract of thesis…candidate of medical sciences. Kazan, 2012. (in Russian)
32. Yavnov S.V. Atlas echinoderms and ascidians Far Eastern seas of Russia. Vladivostok, 2010. (in Russian)
33. Abubakar L., Mwangi C., Uku J., Ndirangu S. Antimicrobial activity of various extracts of the sea urchin Tripneustes gratilla // Afr. J. Pharmacol. Ther. 2012. 1. (1). 19–23.
34. Bandaranayake W.W. The nature and role pigments of marine invertebrates // Nat. Prod. Rep. 2006. 23. 223–255.
35. Chairman K., Aja R.S., Alagomuthu G. Cytotoxic and antioxidant activity of selected marine sponges // Asian Pac. J. Trop. Dis. 2012. 28. 234–238.
36. Cinelli L.P., Vilela E.S., Mourao A.S. Seminal fluid from sea urchin (Lytechinus variegatus) contains complex sulfated polysaccharides linked to protein // Comp. Biochem. Physiol. 2009. 5. 258–265.
37. Cumashi A., Ushakova N.A., Peobrazhenskaya M.E. et al. A comparative study of the anti-inflammatory, anticoagulant, antiangiogenic and antiadhesive activities of nine different fucoidans from brown seaweeds // Glicobiology. 2007. 17. (5). 541–552.
38. Garama D., Bremer P., Carne A. Extraction and analysis of carotenoids from the New Zealand sea urchin Evechinus chloroticus gonads // Acta Biochim. Pol. 2012. 59. (1). 83–85.
39. Gavin N.M., Durako M.J. Localization and antioxidant capacity of flavonoids in Halophila jonsonii in response to experimental light and salinity variation // J. Exp. Mar. Biol. Ecol. 2012. 416. (417). 32–40.
40. Haug T., Kjuul A.K., Styrvold O.B. et al. Antibacterial activity in Strongylocentrotus droebachiensis (Echinoidea), Cucumaria frondosa (Holothuroidea) and Asterias rubens (Asteroidea) // J. Invert. Pathol. 2002. 81. 94–102.
41. Ji J., Wang L., Wu H., Luan H.M. Bio-function summary of marine oiligosaccharides // Int. J. Biol. Sci. 2011. 3 (1). 58–65.
42. Kalogeropoulos N., Mikellidi A., Nomicos T., Chiou A. Screening of macro- and bioactive microconstituents of commercial finfish and sea urchin eggs // LWT Food Sci. Technol. 2012. 46. (2). 525–531.
43. Kuwahara R., Hatate H., Tamami Y. et al. Antioxidant property of polyhidroxilated naphthoquinone pigments from shells of purple sea urchin Anthocidaris crassispina // LWT Food Sci. Technol. 2009. 42. (7). 1296–13000.
44. Le Bouffant R., Cormier P., Cueff A. et al. Sea urchin embrio as a model for analysis of the signaling pathways linking DNA damage checkpoint, DNA repair and apoptosis // Cell Mol. Life Sci. 2007. 64. (13). 1723–1734.
45. Liu C., Lin Q., Gao Y. et al. Characterization and antitumor activity of a polysaccharide from Strongylocentrotus nudus egg // Carbohgydr. Polym. 2007. 67. (3). 313–318.
46. Mamelona J., Saint-Louis R., Pelletier E. Proximate composition and nutritional profile of byproducts from green urchin and Atlantic sea cucumber processing plants // Int. J. Food Sci. Technol. 2010. 45. 2119–2126.
47. Mamelona J., Pelletier E., Girard-Lalancette I. et al. Antioxidants in digestive tracts and gonads of green urchin (Strongylocentrotus droebachiensis) // J. Food Compost. Anal. 2011. 24. (2). 179–183.
48. Matsuno T., Tsushima M. Carotenoids in sea urchins. Amsterdam, 2001.
49. Matsuno T. Aquatic animal carotenoids // Fish. Sci. 2001. 67. (5). 771–783.
50. Montano-Castaneda M.C., Santafe-Patino G.G. Evaluation of antioxidant activity of marine sponges // Actu. Biol. 2011. 33. (95). 173–181.
51. Mueller M., Lucas B., Novak J. et al. Oregano: a source for peroxisome proliferator-activated receptor gamma antagonists // J. Agric. Food. Chem. 2008. 56. (24). 11621–11630.
52. Newman D.J., Cragg G.M. Natural products as sources of new drugs over the last 25 years // J. Nat. Prod. 2007. 70. (3). 461–477.
53. Pomin V.H., Mourao P.A. Structure, biology, evolution and medical importance of sulfated fucans and galactans // Glycobiology. 2008. 18. 1016–1027.
54. Pomin V.H. An overview about the structure-function relationship of marine sulfated homopolysaccharides with regular chemical structures // Biopolymers. 2009. 91. 601–609.
55. Pomin V.H. Structural and functional insights into sulfated galactans: a systematic review // Glycoconjugate J. 2010. 27. 1–12.
56. Pomin V.H. Fucanomics and galactanomics: marine distribution, medicinal impact, conceptions and challenges // Mar. Drugs. 2012. 10. 793–811.
57. Pomin V.H., Mourao P.A.S. Structure versus anticoagulant and antithrombotic action of marine sulfated polysaccharides // Rev. Braz. Farmacogn. 2012. 22. (4). 248–256.
58. Qian Z.J., Jung W.K., Kang K.H. et al. In vitro antioxidant activities Pavlowa lutheri (Haptophyta) with the yeast Hansenula polymorpha // J. Phychol. 2012. 48. (2). 475–482.
59. Quin L., Zhu B.W., Zhou D.Y. et al. Preparation and antioxidant activity of enzymatic hydrolysates from purple sea urchin (Strongylocentrotus nudus) gonad // LWT Food Sci. Technol. 2011. 44. (4). 1113–1118.
60. Riccioni G. Marine carotenoids and oxidative stress // Mar. Drugs. 2012. 10. 116–118.
61. Rodriguez-Bernaldo D.Q.A., Lopez-Hernandes J., Simal-Lozano J. Separation of phospholipid classes in sea urchin Paracentrotus lividus by high-perfomance liquid chromatography // J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 2002. 770. (1–2). 71–75.
62. Shamsuddin A.A., Lukman H., Kumari M.D., Noraznavaty I. Antibacterial activity of three species of sea urchin extracts from Pulau Bidong, Terengganu // J. Sustain. Sci. Manag. 2010. 5. (1). 116–124.
63. Shankarlal S., Prabu K., Natarajan E. Antimicrobial and antioxidant activity of purple sea urchin shell // Am.-Euras. J. Sci. Res. 2011. 6. (3). 178–181.
64. Sheean P., Hodges L.D., Kalafatis N. et al. Bioactivity of extracts from gonadal tissue of the edible Australia purple sea urchin Heliocidaris erythrogramma // J. Sci. Food Agric. 2007. 87. (4). 694–701.
65. Shillaci D., Arizza V., Parrinello N. et al. Antimicrobial and antistaphylococcal biofilm activity from the sea urchin Paracentrotus lividus // J. Appl. Microbiol. 2009. 108. 17–24.
66. Maoka T. Carotenoids in marine animals // Mar. Drugs. 2011. 9. (2). 278–293.
67. Uma B., Parvathavarthini R. Antibacterial effect of hexane extract of sea urchin Temnopleurus alexandri (Bell, 1884) // Int. J. Pharm. Tech. Res. 2010. 2 (3). 1677–1680.
68. Wilson-Sanders S. Invertebrate models for biomedical research, testing and education // 2011. 58. (2). 126–152.
69. Yang R., Wang J., Liu Z. et al. Antioxidant effect of a marine oligopeptide preparation from Chum Salmon (Oncorhynchus keta) by enzymatic hydrolysis in radiation injured mice // Mar. Drugs. 2011. 9. (11). 2304–2315.
70. Zhou D., Qin L., Zhu B. et al. Optimization of hydrolysis of purple sea urchin gonad by response surface methodology and evaluation of in vitro antioxidant activity of the hydrolysate // J. Sci. Food Agric. 2012. 92. (8). 1694–1701.
Kryzhanovski S.P. – candidate of medical sciences, head doctor