Dynamics of serum triglycerides and lipoproteins in rats with carcinosarcoma Walker 256 after general hyperthermia
The growth of carcinosarcoma Walker 256 in rats passes several stages distinguishing by the nature of metabolic processes in the organism. The aim of the study was to monitor the dynamics of lipid metabolism during tumor growing and evaluate the influence of general hyperthermia on main parameters of serum lipids. Experiments were carried out on Wistar line rats with carcinoma Walker 256. General hyperthermia was conducted according to the author’s protocol, patent 2165105 of the Russian Federation. Lipid content of blood serum was defined by standard biochemical methods used in the clinical practice. It was found that the growth of tumors Walker 256 is accompanied with significant increase in triglycerides and very low density lipoproteins levels on the background of reducing high density lipoproteins. Hyperthermia intensifies additionally a shift of these lipid metabolic parameters in the same direction. The increase in the alive animals amount on late and terminal stages of carcinosarcoma Walker 256 progressing in rats was revealed after general hyperthermia, the increase correlated with the change in triglycerides and very low density lipoproteins levels. The effect can be connected with functioning conditions of tumor vascular system.
About Authors (Correspondence):
Molokov K.V. – postgraduate student of the department of pathological physiology and clinical pathophysiology, e-mail: firstname.lastname@example.org
Khegay I.I. – doctor of biological sciences, senior researcher
Efremov A.V. – doctor of medical sciences, professor, corresponding member of the RAMS, head of the department of pathological physiology and clinical pathophysiology