Morphofunctional parameters of peritoneal macrophages of different mice strains at aseptic inflammation
Abstract
This paper reports a decrease in macrophage chemotaxis in response to aseptic inflammation (induced by starch introduction) of A/Sn mice by3 times and Balb/c lines by 1.6 times as compared to albino mice macrophages. Adhesion of A/Sn mice macrophages to the substrate is reduced by 1.6 times in comparison with two other species. Activity of matrix metalloproteinases 2.7 in macrophage homogenates was shown to be increased in all lines when macrophages were cultured for 7 days. In spite of this the dynamics of enzyme activity growth is in correlation morphological characteristics of the cells (adhesion, spreading, monolayer formation and contact inhibition). The initial activity of matrix metalloproteinases of macrophages to be decreased in A/Sn mice and increased in Balb/c mice as compared with the macrophages of albino mice.
Key words
Miroshnichenko S.M.– researcher of laboratory of molecular mechanisms of intercellular interactions, e-mail: svmiro@yandex.ru
Kovalenko G.A. – candidate of medical sciences, senior researcher of laboratory of molecular mechanisms of intercellular interactions, e-mail: ibch@soramn.ru
Russkikh G.S. – candidate of medical sciences, senior researcher of laboratory of medical biotechnology, e-mail: Russkich_@soramn.ru
Poteryaeva O.N. – doctor of medical sciences, professor of the general and bioorganic chemistry department, e-mail: Olga_Poteryaeva@mail.ru
Panin L.E. – doctor of medical sciences, academician of RAMS, director, e-mail: ibch@soramn.ru
