Hormonal and biochemical features of alloxan and streptozotocin-induced models of experimental diabetes

The diabetic uremic syndrome with death within the first five days after drug administration has been revealed in 31 % of animals after administration to male Wistar rats diabetogenic dose of alloxan (170 mg / kg body weight); 45 % of the animals demonstrated high sensitivity and 34 % - low sensitivity to diabetogenic action of the drug. The animal deaths have not been observed after administration to rats diabetogenic dose of streptozotocin (50 mg/kg body weight); 55 % of the animals demonstrated high sensitivity and 45 % - low sensitivity to the diabetogenic effects of the drug. Highly-sensitive to the action of alloxan or streptozotocin rats, despite the different mechanisms of injury insular apparatus of the pancreas are similar by intensity of the changes of hormonal and biochemical parameters in 14-21 days after drug administration and can be effectively used to study the effects of hypoinsulinemia and correction of hyperglycemia with various drugs.

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Palchikova N.A. - doctor of biological sciences, leading researcher, е-mail: labend@mail.ru
Kuznetsova N.V. - researcher, е-mail: labend@soramn.ru
Kuzminova O.I. - candidate of medical sciences, senior researcher, е-mail: labend@soramn.ru
Selyatitskaya V.G. - doctor of biological sciences, professor, head of the laboratory, е-mail: ccem@soramn.ru