The Siberian Scientific Medical Journal
№ 6 / 2013 / 25-30

Histochemical and immunohistochemical investigation of extracellular matrix of fibrous ring of intervertebral discs at staphylococcosis modeling

Author Affiliations


RESEARCH OBJECTIVE: to study the changes of an extracellular matrix of a fibrous ring of intervertebral disks at modelling staphylococcal infection. MATERIAL AND METHODS: 18 males Wistar with tibia bone osteomyelitis and 6 control animals; histochemistry and immunohistochemistry on the basis of the automatic analysis of fibrocartilage image at 1, 2 and 3 months after osteomyelitis development. RESULTS AND DISCUSSION: reorganization of the extracellular matrix of the fibrous ring has been revealed at the long-term staphylococcal infection that is the response to occurring degenerative changes in intervertebral disks.

Key words

Staphylococcus аureus, histochemistry, immunohistochemistry, intervertebral disk, fibrous ring, extracellular matrix
About Authors (Correspondence):

Zhurakovski I.P. - candidate of medical sciences, senior researcher, e-mail:
Arkhipov S.A. - doctor of biological sciences, senior researcher
Pustovetova M.G. - doctor of medical sciences, professor, head of the central scientific research laboratory
Golubeva I.A. - doctor of medical sciences, professor of the chair for anatomy
Marinkin I.O. - doctor of medical sciences, professor, rector
Elyasin P.A. - candidate of medical sciences, assistant professor of the chair for anatomy

Full Text

Received: 11/02/2015