Histochemical and immunohistochemical investigation of extracellular matrix of fibrous ring of intervertebral discs at staphylococcosis modeling
Author Affiliations1Novosibirsk State Medical University of Federal Agency of Public Health and Social Development 630009, Novosibirsk, Krasnyi av., 52
2Novosibirsk State Medical University of Federal Agency of Public Health and Social Development 630009, Novosibirsk, Krasnyi av., 52
3Novosibirsk State Medical University of Minzdrav of Russia 630091, Novosibirsk, Krasny av., 52
4Novosibirsk State Medical University of Federal Agency of Public Health and Social Development 630009, Novosibirsk, Krasnyi av., 52
5Novosibirsk State Medical University of Minzdrav of Russia 630091 , Novosibirsk, Krasny av., 52
6Novosibirsk State Medical University of Minzdrav of Russia 630091, Novosibirsk, Krasny av., 52
Abstract
RESEARCH OBJECTIVE: to study the changes of an extracellular matrix of a fibrous ring of intervertebral disks at modelling staphylococcal infection. MATERIAL AND METHODS: 18 males Wistar with tibia bone osteomyelitis and 6 control animals; histochemistry and immunohistochemistry on the basis of the automatic analysis of fibrocartilage image at 1, 2 and 3 months after osteomyelitis development. RESULTS AND DISCUSSION: reorganization of the extracellular matrix of the fibrous ring has been revealed at the long-term staphylococcal infection that is the response to occurring degenerative changes in intervertebral disks.
Key words
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About Authors (Correspondence):
Zhurakovski I.P. - candidate of medical sciences, senior researcher, e-mail: murash2003@yandex.ru
Arkhipov S.A. - doctor of biological sciences, senior researcher
Pustovetova M.G. - doctor of medical sciences, professor, head of the central scientific research laboratory
Golubeva I.A. - doctor of medical sciences, professor of the chair for anatomy
Marinkin I.O. - doctor of medical sciences, professor, rector
Elyasin P.A. - candidate of medical sciences, assistant professor of the chair for anatomy
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