Comparative analysis of expression of molecular markers of lymphatic vessels LYVE-1 and podoplanin at the lower lip cancer and skin melanoma

Immunohistochemical research of lymphatic vasculature of 2 type tumors differing in malignant growth aggression and metastatic potential - squamous cell carcinomas of lower lip and melanoma of skin has been carried out. The antibodies to markers of lymphatic vessels endotheliocytes LYVE and podoplanin were used. In both cases the bigger contents of podoplanin positive lymphatic vessels in comparison with LYVE-1+ vessels where revealed. The more considerable, than at the lower lip cancer, prevalence of expressing podoplanin vessels in the circumferential direction of tumor growth in comparison with boundary sites of tumor at melanoma of skin probably testifies to the lymphatic vessels new formation. Noted distinctions from lymphatic network development among patients with melanoma of skin can be connected with the disease progressing that demands further researches.

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Bgatova N.P. - doctor of biological sciences, professor, head of the laboratory, e-mail: n_bgatova@ngs.ru
Kulikova I.S. - correspondence postgraduate student, e-mail kis1975@rambler.ru
Lomakin A.I. - correspondence postgraduate student, e-mail lomakin@rocketmail.com
Isakova N.B. - pathologist, e-mail nadin-isakova@mail.ru
Prokhozhev V.B. - pathologist
Kachesov I.V. - head of pathoanatomical department, chief pathologist
Fursov S.A. - doctor of medical sciences, professor of the chair of oncology, surgeon of the highest category, head of surgical department, e-mail fursov.serega2011@yandex.ru
Borodin Yu.I. - doctor of medical sciences, professor, academician of RAMS, e-mail lympha@soramn.ru
Narov Yu.E. - doctor of medical sciences, professor, head of the chair for oncology
Letyagin A.Yu. - doctor of medical sciences, professor, deputy director on scientific work, e-mail letyagin-andrey@yandex.ru
Voytsitskiy B.E. - doctor of medical sciences, professor of the chair of oncology, deputy chief physician on medical department, chief oncologist
Konenkov V.I. - doctor of medical sciences, professor, academician of RAMS, director, e-mail konenkov@soramn.ru