The Siberian Scientific Medical Journal
№ 2 / 2013 / 99-108

Achievements and future of research of the role of cytokine genes polymorphisms in the pathogenesis of multiple sclerosis (review)

Author Affiliations


It has been proved that multiple sclerosis is a multifactorial polygenic disease. The review of the literature on recent achievements of research of cytokine genes polymorphisms in the pathogenesis of MS and the prospects for the data practical application has been carried out. Original articles and reviews on the results of genome-wide association studies and powerful candidate gene investigations have been analyzed. The biological role of the inflammatory cytokines and the association of polymorphic markers of the disease were described. Thereat besides the issue on susceptibility factors to MS, variants of genes that could determine the clinical phenotype and the clinical outcome are actively investigated.

Key words

GWAS, SNP, gene CD40, IL18 gene, TNF gene, genotyping, cytokine gene polymorphisms, Multiple sclerosis
About Authors (Correspondence):

Korobko D.S. – neurologist, e-mail:;

Malkova N.A. – doctor of medical sciences, professor of the chair for clinical neurology and algology

Full Text

Received: 11/02/2015