The Siberian Scientific Medical Journal
 
 
№ 4 / 2013 / 35-41

Comparative study on the migration and distribution of bone marrow and spleen cells into lymphoid and non-lymphoid organs of CBA mice in vivo in different periods after transplantation

Author Affiliations

Abstract

The purpose of this study was to examine the migration activity and distribution of in vivo bone marrow cells and splenocytes of male CBA intravenous transplantation in syngeneic females. As a marker of cell donor was used Y chromosome sry gene of male donor bone marrow cells and spleen cells. The dynamics of migration and comparative analysis of the distribution of sry-positive cells of bone marrow and spleen donor males in different periods after intravenous transplantation (after 1 hour, 24 hours, 1 month, 3 months) in skin, lymph nodes, liver, spleen, heart, brain, bone marrow of the organs of syngeneic recipients, female CBA mice have been studied. It has been found that bone marrow and spleen cells migrate with different dynamic into all studied organs, both into lymphoid and non–lymphoid during all periods after transplantation.

Key words

Y chromosome sry gene, bone marrow cells, migration, spleen cells
References
About Authors (Correspondence):

Solovieva A.O. – junior researcher, e-mail: solovevaao@yandex.ru

Poveshchenko A.F. – doctor of medical sciences, head of the laboratory, e-mail: poveshchenkoa200@mail.ru

Poveshchenko O.V. – candidate of medical sciences, head of the laboratory, e-mail: PoveschenkoOV@yandex.ru

Zubareva K.E. – junior researcher, e-mail: zubareva_kje@vector.nsc.ru

Miller T.V. – postgraduate student, e-mail: tmw87@mail.ru

Konenkov V.I. – doctor of medical sciences, professor, academician of RAMS, director, e-mail: konenkov@soramn.ru

Full Text

Received: 02/02/2015