Interrelation between carbohydrate metabolism, anthropometric status and bone tissue condition at women in perimenopause
Author Affiliations1Novosibirsk State Medical University of Minzdrav of Russia 630091, Novosibirsk, Krasnyi av., 52
2Novosibirsk State Medical University of Minzdrav of Russia 630091, Novosibirsk, Krasnyi av., 52; «Russian Railways» Open Joint Stock Company Railway Clinical Hospital on the Station Novosibirsk-Glavnyi 630003, Novosibirsk, Vladimirovskiy spusk, 2а
3Novosibirsk State Medical University of Minzdrav of Russia 630091, Novosibirsk, Krasnyi av., 52
Abstract
The aim of the study – to evaluate the relationship of carbohydrate and anthropometric parameters with the state of bone tissue. Material and Methods: 40 pre- and postmenopausal females with type 2 diabetes and 40 with normoglycemia. Body mass index, waist circumference, blood glucose, glycated hemoglobin, bone densitometry were determined. Results and discussion. Critical values for these parameters that determine the risk of osteoporosis were identified. These data were confirmed by revealed correlation influence (the highest influence in case of postprandial hyperglycemia) on the bone mineral density with maximal osteoporosis risk in the proximal femur.
Key words
References
- Grigorya O.P., Andreeva E.N. Menopausal syndrome in women with disorders of carbohydrate metabolism. Alternative and additional methods of therapy in climacteric (review). Ginekologiya. 2011.3.- P.4-7 (In Russian)
- Dedov I.I., Shestakova M.V. (Ed.). Algorithms of special medical help to patients with diabetes. М.; 2011 (In Russian)
- Rozhinskaya L.Ya. Systemic osteoporosis: Handbook for physicians. М, 2000.196 p. (In Russian)
- Ruyatkina L.A., Bondareva Z.G., Fedorova E.L., Nesterenko E.V., Ruyatkin D.S. Hormones producing function of ovary in women of yang and average age with arterial hypertension and IHD. Klinicheskaya meditsina. 2005. 2.P.40-44. (In Russian)
- Shishkova V.N. Obesity and osteoporosis (review). Osteoporoz i osteopatiya. 2011.1. (In Russian)
- Carey D.G., Jenkins A.B., Campbell L.V. et al. Abdominal fat and insulin resistance in normal and overweight women: Direct measurements reveal a strong relationship in subjects at both low and high risk of NIDDM // Diabetes. 1996. 45. (5). 633–638.
- Cutrim D.M., Pereira F.A., de Paula F.J., Foss M.C. Lack of relationship between glycemic control and bone mineral density in type 2 diabetes melli- tus // Braz. J. Med. Biol. Res. 2007. 40. (2). 221–227.
- Gerdhem P., Akesson K. Rates of fracture in participants and non-participants in the Osteoporosis Prospective Risk Assessment study // J. Bone Joint Surg. Br. 2007. 89. (12). 1627–1631.
- Gilsanz V., Chalfant J., Mo A.O. et al. Reciprocal relations of subcutaneous and visceral fat to bone structure and strength // J. Clin. Endocrinol. Metab. 2009. 94. (9). 3387–3393.
- Janghorbani M., Van Dam R.M., Willett W.C. et al. Systematic review of type 1 and type 2 diabetes mellitus and risk of fracture // Am. J. Epidemiol. 2007. 166. (5). 495–505.
- Kahn S.E., Zinman B., Lachin J.M. et al. Diabetes Outcome Progression Trial (ADOPT) Study Group. Rosiglitazone-associated fractures in type 2 diabetes: an Analysis from A Diabetes Outcome Progression Trial (ADOPT) // Diabetes Care. 2008. 31. (5). 845–851.
- Kiel D.P., Kauppila L.I., Cupples L.A. et al. Bone loss and the progression of abdominal aortic calcification over a 25-year period: the Framingham heart study // Calcif. Tissue Int. 2001. 68. 271–276.
- Lieben L., Callewaert F., Bouillon R. Bone and metabolism: a complex crosstalk // Horm. Res. 2009. 71. (Suppl. 1). 134–138.
- Monami M., Dicembrini I., Antenore A., Man- nucci E. Dipeptidyl peptidase-4 inhibitors and bone fractures: a meta-anlysis of randomized clinical trials // Diabetes Care. 2011. 34. (11). 2474–2476.
- Muscogiuri G., Sorice G.P., Prioletta A. et al. 25-Hydroxyvitamin D concentration correlates with insulin-sensitivity and BMI in obesity // Obesity (Silver Spring). 2010. 18. (10). 1906–1910.
- Nicodemus K.K., Folsom A.R. Iowa Women's Health Study. Type 1 and type 2 diabetes and incident hip fractures in postmenopausal women // Diabetes Care. 2001. 24. (7). 1192–1197.
- Poehlman E.T., Tchernof A. Traversing the menopause: changes in energy expenditure and body composition // Coronary Artery Dis. 1998. 9. 799–803.
- Premaor M.O., Pilbrow L., Tonkin C. et al. Obesity and fractures in postmenopausal women // J. Bone Mineral Res. 2010. 25. (2). 292–297.
- Simkin-Silverman L.R., Wing R.R., Boraz M.A. et al. Maintenance of cardiovascular risk factor changes among middle-aged women in a lifestyle intervention trial // Womens Health. 1998. 4. (3). 255–271.
- Vestergaard P. Discrepancies in bone mineral density and fracture risk in patients with type 1 and type 2 diabetes – a meta-analysis // Osteoporos Int. 2007. 18. (4). 427–444.
- Yamaguchi T., Sugimoto T. Bone metabolism and fracture risk in type 2 diabetes mellitus // Endocr. J. 2011. 58. (8). 613–624.
Full Text