№ 2 / 2015 / 74-79

Association study of new genetic markers of type 2 diabetes mellitus in West Siberian Caucasian population

Author: Orlov P.S.¹, Ivanoshchuk D.Ye.², Mikhaylova S.V.³, Maksimov V.N.⁴, Voevoda M.I.⁵

Abstract

The aim of the study was to estimate frequencies of the following polymorphisms, including the FTO gene rs9939609, TCF7L2 gene rs7903146, chromosome 9 rs10811661, and KCNQ1 gene rs2237892, in the sample of patients with type 2 diabetes mellitus and in the control group in order to clarify their contribution to the probability of type 2 diabetes mellitus in West Siberian Caucasians. Materials and Methods: the case-control study design was used; 175 individuals (78 men and 97 women) with the confirmed type 2 diabetes mellitus diagnosis and/or with an increased blood glucose level (more than 11.1 mmol/l). 273 individuals (113 men and 160 women) with normal glucose level were selected as a control. Results: the TCF7L2 gene rs7903146 TT genotype is associated with predisposition to type 2 diabetes mellitus (p = 0.038; OR = 2.35). The rs10811661 TT genotype and T allele are associated with predisposition to T2DM (OR = 2.1, p = 0.004; and OR = 1.92, p = 0.004, respectively).

Key words

9 chromosome, FTO, KCNQ1, TСF7L2, SNP, diabetes mellitus type 2

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About Authors (Correspondence):

Orlov P.S. – junior researcher, e-mail: dinara2084@mail.ru

Ivanoshchuk D.Ye. – junior researcher, e-mail: dinara2084@mail.ru

Mikhaylova S.V. – researcher

Maksimov V.N. – doctor of medical sciences, head of laboratory for molecular genetic studies of therapeutic diseases, e-mail: medik11@mail.ru

Voevoda M.I. – doctor of medical sciences, professor, corresponding member of the RAS, e-mail: mvoevoda@ya.ru

Full Text

13-2-2015.pdf

Received: 17/04/2015