The Siberian Scientific Medical Journal
№ 2 / 2015 / 74-79

Association study of new genetic markers of type 2 diabetes mellitus in West Siberian Caucasian population

Author Affiliations


The aim of the study was to estimate frequencies of the following polymorphisms, including the FTO gene rs9939609, TCF7L2 gene rs7903146, chromosome 9 rs10811661, and KCNQ1 gene rs2237892, in the sample of patients with type 2 diabetes mellitus and in the control group in order to clarify their contribution to the probability of type 2 diabetes mellitus in West Siberian Caucasians. Materials and Methods: the case-control study design was used; 175 individuals (78 men and 97 women) with the confirmed type 2 diabetes mellitus diagnosis and/or with an increased blood glucose level (more than 11.1 mmol/l). 273 individuals (113 men and 160 women) with normal glucose level were selected as a control. Results: the TCF7L2 gene rs7903146 TT genotype is associated with predisposition to type 2 diabetes mellitus (p = 0.038; OR = 2.35). The rs10811661 TT genotype and T allele are associated with predisposition to T2DM (OR = 2.1, p = 0.004; and OR = 1.92, p = 0.004, respectively).

Key words

9 chromosome, FTO, KCNQ1, TСF7L2, SNP, diabetes mellitus type 2
About Authors (Correspondence):

Orlov P.S. – junior researcher, e-mail:

Ivanoshchuk D.Ye. – junior researcher, e-mail:

Mikhaylova S.V. – researcher

Maksimov V.N. – doctor of medical sciences, head of laboratory for molecular genetic studies of therapeutic diseases, e-mail:

Voevoda M.I. – doctor of medical sciences, professor, corresponding member of the RAS, e-mail:

Full Text

Received: 17/04/2015