The Siberian Scientific Medical Journal
№ 3 / 2015 / 21-24

Screening method of non-steroidal anti-inflammatory drug induced intestinal failure indentification in patients at high risk orthopedic operations

Author Affiliations


Patients with degenerative joint disease take non-steroid anti-inflammatory drugs (NSAIDs) for a long time. Clinical laboratory, endoscopic, morphological, bacteriological data indicate the presence of chronic intestinal failure (CIF). The problem of CIF screening of patients with cox and gonarthrosis on the background of NSAIDs intake at high risk orthopedic surgery remains actual. The content of fecal calprotectin (FC) and pH of intestinal samples from 160 patients with cox and gonarthrosis with CIF have been investigated. After analyzing the dynamics of the FC and the pH of feces and clinical and biochemical, endoscopic, morphological, bacteriological parallel, it can be stated that the increase in these indicators testifies to the pronounced changes in the gastrointestinal tract. The direct correlation between the concentration of FC (rS = 0.632, p = 0.001) and pH of feces (rS = 0.598, p = 0.001) was revealed. This statistical fact allows using and applying pH feces as the screening method to identify NSAID-induced CIF.

Key words

intestinal failure, prosthetic knee and hip joints, screening, fecalniy calprotectin
About Authors (Correspondence):

Kirilina S.I. – doctor of medical sciences, e-mail:

Sirota V.S. – anesthesiologist-resuscitator, е-mail:

Ivanova E.Yu. – anesthesiologist – resuscitator

Pavlov V.V. – doctor of medical sciences, head of department, traumatologist orthopedist

Prokhorenko V.M. – doctor of medical sciences, professor

Baitov V.S. – senior researcher of department for endoprosthesis replacement, e-mail:

Full Text

Received: 01/07/2015