Life quality in lung cancer patients undergoing combined modality treatment including intraoperative radiation therapy
Life quality of 140 patients with stage III non-small cell lung cancer who received combined modality treatment including neoadjuvant chemotherapy with paclitaxel/carboplatin, radical surgery and 15 Gy intraoperative radiation therapy with concurrent cisplatin was studied. To assess life quality of lung cancer patients, EORTC QLQ–30 (version 3.0) and EORTC QLQ–LC13 questionnaires were used. Life quality was shown to be depended on chemotherapy regimens and the extent of surgery. Neoadjuvant chemotherapy resulted in increase in physical functioning from 82.8 ± 5.3 % to 91.6 ± 2.4 % and general health status from 61.5 ± 7.1 % to 72.0 ± 4.2 %. After surgery, functional status of life quality depended on the extent of surgery. The functional status was worse after pneumonectomy than after lung resection (53.7 ± 5.5 % versus 66.0 ± 4.8 %). Intraoperative radiotherapy at a single dose of 15 Gy and radiosensitization with cisplatin did not have statistically significant impact on life quality. The final stage of rehabilitation after combined modality treatment occurred within 12 months.
About Authors (Correspondence):
Zavyalov A.A. – doctor of medical sciences, leading researcher of the thoracic-abdominal department, e-mail: firstname.lastname@example.org
Dobrodeev A.Yu. – doctor of medical sciences, leading researcher of the thoracic-abdominal department, e-mail: email@example.com
Tuzikov S.A. – doctor of medical sciences, professor, head of the thoracic-abdominal department, e-mail: firstname.lastname@example.org