On the role of basal cortisol levels in affective and cognitive impairment in patients with chronic cerebral ischemia accompanied with psychosomatic diseases
Author Affiliations1Novosibirsk State Medical University of Minzdrav of Russia, 630000, Novosibirsk, Krasny av., 52
2Novosibirsk State Medical University of Minzdrav of Russia, 630000, Novosibirsk, Krasny av., 52
3Novosibirsk State Medical University of Minzdrav of Russia, 630000, Novosibirsk, Krasny av., 52
4Institute of Physiology and Basic Medicine, 630117, Novosibirsk, Timakov str., 4
Abstract
Aim. The study was aimed to identify the relationship of basal cortisol levels with anxiety, depression, stress resilience, and severity of cognitive impairment in patients with chronic cerebral ischemia accompanied by psychosomatic diseases. Material and methods. The estimation of the basal cortisol levels in the blood and psychometric parameters in 110 patients of neurological department with diagnosed chronic cerebral ischemia was performed. On one hand, these changes were analyzed with respect to age group (46–60, 61–74, or 75–79 years). On the other hand, the data were analyzed with respect to patients’ history of comorbidities (peptic ulcer, postinfarction cardiosclerosis) which can be regarded as psychosomatic illness. Results. In the group of patients with postinfarction cardiosclerosis, cortisol was higher compared to the control, but did not differ from the group of patients with a history of peptic ulcer disease. In these groups higher rates on the scale of the hospital anxiety and depression (HADS) and lower stress resilience were detected. Age-related increase in anxiety and depression, and diminished stress resistance were revealed. Conclusion. Patients with psychosomatic diseases, regardless of their type, were characterized by higher values of cortisol level which were associated with more severe affective and cognitive impairment. According to the regression analysis, cortisol can be considered as a prognostic factor with respect to cognitive dysfunction, anxiety, depression, and stress resilience in patients with chronic cerebral ischemia in middle and old age.
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About Authors (Correspondence):
Shevchenko A.V. – postgraduate student, neurologist, e-mail: av.shevchenko80@mail.ru
Doronin B.M. – doctor of medical sciences, head of the department of neurology, e-mail: b_doronin@mail.ru
Doronina O.B. – candidate of medical sciences, associate professor of the department of neurology, e-mail: neurocentr@mail.ru
Amstislavskaya T.G. – doctor of biological sciences, head of laboratory of experimental models of emotional pathology, deputy director for science, e-mail: amstislavskaya@yandex.ru
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