The Siberian Scientific Medical Journal
№ 5 / 2015 / 5-25

Keap1/Nrf2/ARE redox-sensitive system as a phagmacological target in cardiovascular diseases

Author Affiliations


Attempts to prevent cardiovascular diseases by means of antioxidant vitamins have generally been unsuccessful. This has led to the emergence of a new trend: influence on Keap1/Nrf2/ARE redox-sensitive signaling system, which regulates the intracellular levels of endogenous intracellular antioxidants. The positive impact of the transcription factor Nrf2 inducers in cardiovascular diseases is well evidenced, but many questions of their prophylactic use remain. The analysis of the prospects of the use of different classes of Keap1/Nrf2/ARE system pharmacological inducers in cardiovascular diseases has been performed.

Key words

redox-regulation, cardiovascular diseases, Keap1/Nrf2/ARE signal system
About Authors (Correspondence):

Zenkov N.K. – doctor of biological sciences, leading researcher, e-mail:

Kolpakov A.R. – doctor of medical sciences, professor,

Menshchikova E.B. – doctor of medical sciences, head of the laboratory, e-mail:

Full Text

Received: 02/11/2015