Редокс-чувствительная система Keap1/Nrf2/ARE как фармакологическая мишень при сердечно-сосудистой патологии
Реферат
Неудачные попытки профилактики сердечно-сосудистых заболеваний с помощью антиоксидантных витаминов привели к появлению нового направления воздействий на редокс-чувствительную сигнальную систему Keap1/Nrf2/ARE, регулирующую уровень эндогенных внутриклеточных антиоксидантов. Несмотря на большое количество свидетельств положительного влияния активаторов транскрипционного фактора Nrf2 на заболевания сердечно-сосудистой системы, многие вопросы их профилактического применения остаются нерешенными. Мы провели анализ перспективности применения различных классов фармакологических индукторов системы Keap1/Nrf2/ARE при сердечно-сосудистых заболеваниях.
Тэги
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Зенков Н.К. – д.б.н., ведущий научный сотрудник, е-mail: lemen@centercem.ru
Колпаков А.Р. – д.м.н., проф., e-mail: kolpakov2@yandex.ru
Меньщикова Е.Б. – д.м.н., зав. лабораторией, е-mail: lemen@centercem.ru
