Ultrastructural characterization of the myocardium in mechanical trauma of the heart in the experiment
Author Affiliations1Novosibirsk State Medical University of Minzdrav of Russia, 630091, Novosibirsk, Krasny av., 52
2Novosibirsk State Medical University of Minzdrav of Russia, 630091, Novosibirsk, Krasny av., 52
3Novosibirsk State Medical University of Minzdrav of Russia, 630091, Novosibirsk, Krasny av., 52
4Novosibirsk State Medical University of Minzdrav of Russia, 630091, Novosibirsk, Krasny av., 52
5Altai State Medical University of Minzdrav of Russia, 656038, Barnaul, Lenin av., 40
6Novosibirsk State Medical University of Minzdrav of Russia, 630091, Novosibirsk, Krasny av., 52
7Novosibirsk State Medical University of Minzdrav of Russia, 630091, Novosibirsk, Krasny av., 52
8Novosibirsk State Medical University, 630091, Novosibirsk, Krasnyi av., 52
9Novosibirsk State Medical University of Minzdrav of Russia, 630091, Novosibirsk, Krasny av., 52
Abstract
Conducted a study to identify changes in the ultrastructure of cardiomyocytes and endothelial cells of blood capillaries of the myocardium of the ventricles of the heart in its mechanical damage of varying severity. Experimental modeling of the closed mechanical damage of the heart in rats of Wistar breed using original techniques. The study showed that the increase in the volume density of mitochondria, sarcoplasmic reticulum, lysosomes and decrease in the volume density of ribosomes and glycogen took place at heart damage in the form of its injury in cardiomyocytes. The increase in the volume density of mitochondria and micropinocytosis vesicles and decrease in the volume density of ribosomes have been observed in endothelial cells of the myocardium. The severity of these changes depends on the severity of mechanical damage of the myocardium. These disorders, in our opinion, play the determined role in the development of acute contractile failure of the myocardium in case of heart mechanical damage
Key words
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About Authors (Correspondence):
Novoselov V.P. – doctor of medical sciences, head of department of forensic medicine, e-mail: sme.ngmu@mail.ru
Savchenko S.V. – doctor of medical sciences, professor of the department of forensic medicine,
e-mail: sme.ngmu@mail.ru
Porvin A.N. – assistant of the department of forensic medicine, e-mail: sme.ngmu@mail.ru
Koshlyak D.A. – candidate of medical sciences, assistant of the department of forensic medicine, e-mail: sme.ngmu@mail.ru
Yankovskiy V.E. – doctor of medical sciences, professor of the department of forensic medicine and law, e-mail: yankovsckiy-sme@yandex.ru
Nadeev A.P. – doctor of medical sciences, head of the department of pathological anatomy, e-mail: nadeevngma@mail
Ageeva T.A. – doctor of medical sciences, professor of the department of pathological anatomy, e-mail: pat_anat@mail.ru
Chikinev Yu.V. – doctor of medical sciences, head of the department of hospital and pediatric surgery, e-mail: chikinev@inbox.ru
Polyakevich A.S. – doctor of medical sciences, associate professor, of the department of hospital and pediatric surgery, e-mail: randorier@mail.ru
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